Related Experiment Video

Updated: Jun 26, 2026

In Vitro Modeling of Down Syndrome Neurogenesis Using Human-Induced Pluripotent Stem Cells
06:38

In Vitro Modeling of Down Syndrome Neurogenesis Using Human-Induced Pluripotent Stem Cells

Published on: March 7, 2025

Generation of integration-free induced pluripotent stem cell line (KSCBi024-A) from patients with down syndrome

Young Sam Im1, Yong-Ou Kim1, Sun-Jung Cho1

  • 1Division of Intractable Diseases Research, Korea National Institute of Health, Osong, Cheongju-si, South Korea.

Stem Cell Research
|June 24, 2026
PubMed

Keywords:
Down syndromeKSCBi024-ANSCBTrisomy 21

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Stem cells are undifferentiated cells that divide and produce different cell types. Ordinarily, cells that have differentiated into a specific cell type are terminally differentiated; however, scientists have found a way to reprogram these mature cells so that they dedifferentiate and return to an unspecialized, proliferative state. These cells are pluripotent like embryonic stem cells—able to produce all cell types—and are called induced pluripotent stem cells (iPSCs).
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