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Related Concept Videos

Bone Remodeling01:40

Bone Remodeling

Bone remodeling is a continuous and balanced process of bone resorption by osteoclasts and bone formation by osteoblasts. In adults, it helps maintain bone mass and calcium homeostasis. While mechanical stress can stimulate turnover as part of the normal maintenance and reparative process, several hormones also regulate bone remodeling.
Bone Remodeling and Repair01:31

Bone Remodeling and Repair

Osteoclasts are cells responsible for bone resorption and remodeling. They originate from hematopoietic progenitor cells present in the bone marrow. Numerous progenitor cells fuse to form multinucleated cells, each with 10-20 nuclei. A single osteoclast has a diameter of 150 to 200 µM. These cells have ruffled borders that break down the underlying bone tissue and release minerals such as calcium into the blood in bone resorption. Osteoclasts cling to bones with their ruffled edges during bone...

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Related Experiment Video

Updated: Jun 25, 2026

Using Inducible Osteoblastic Lineage-Specific Stat3 Knockout Mice to Study Alveolar Bone Remodeling During Orthodontic Tooth Movement
05:25

Using Inducible Osteoblastic Lineage-Specific Stat3 Knockout Mice to Study Alveolar Bone Remodeling During Orthodontic Tooth Movement

Published on: July 21, 2023

Predicting site-specific alveolar bone remodeling in class III decompensation: a preliminary study based on a

Jiaming Li1, Xiao Xu1, Yue Wu2

  • 1Department of Periodontology, Peking University School and Hospital of Stomatology & National Center for Stomatology & National Clinical Research Center for Oral Diseases & National Engineering Research Center of Oral Biomaterials and Digital Medical Devices, No.22, Zhongguancun South Avenue, Haidian District, Beijing, 100081, PR China.

BMC Oral Health
|June 24, 2026
PubMed
Summary

This study developed a data-driven framework using a radial basis function (RBF) neural network to predict alveolar bone remodeling during orthodontic treatment for Class III malocclusion, improving personalized care.

Keywords:
Alveolar bone remodelingCone-beam computed tomographyNeural networkOrthodontic decompensationPrediction modelSkeletal Class III malocclusion

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Area of Science:

  • Orthodontics
  • Biomedical Engineering
  • Data Science

Background:

  • Skeletal Class III malocclusion often requires mandibular incisor decompensation.
  • Predicting alveolar bone remodeling is crucial for successful orthodontic outcomes.
  • Current methods lack precision in site-specific bone change prediction.

Purpose of the Study:

  • To develop and validate a data-driven framework for predicting site-specific alveolar bone remodeling.
  • To utilize a radial basis function (RBF) neural network for this prediction.
  • To enhance treatment planning for mandibular incisor decompensation in Class III malocclusion.

Main Methods:

  • Retrospective cohort study of 10 patients (39 incisors).
  • 3D analysis of pre- and post-treatment cone-beam computed tomography scans.
  • Quantification of tooth movement and RBF neural network modeling of bone response.

Main Results:

  • Identified distinct compression-side resorption limits and tension-side apposition gradients.
  • RBF model achieved high accuracy (R 2 =0.7-0.9) in predicting bone thickness.
  • Demonstrated the model's ability to capture nonlinear interactions and anatomical constraints.

Conclusions:

  • The framework accurately quantifies and predicts site-specific alveolar bone responses.
  • Bone remodeling is influenced by tooth movement patterns and anatomical limitations.
  • Enables preemptive risk assessment and personalized orthodontic treatment planning.