Association Between MTHFR Gene Polymorphisms and Subclinical Hypothyroidism in Early Pregnancy: A Retrospective...

Area of Science:

• Genetics
• Obstetrics
• Endocrinology

Background:

• Subclinical hypothyroidism (SCH) in early pregnancy poses risks to both mother and fetus.
• Methylenetetrahydrofolate reductase (MTHFR) gene polymorphisms are implicated in various pregnancy complications.
• Understanding the genetic factors associated with SCH is crucial for early detection and management.

Purpose of the Study:

• To investigate the association between MTHFR gene polymorphisms (C677T and A1298C) and SCH in pregnant women.
• To identify other potential risk factors for SCH in early pregnancy.

Main Methods:

• A retrospective case-control study involving 100 pregnant women with SCH and 300 controls.
• MTHFR C677T and A1298C polymorphisms analyzed using PCR-RFLP.
• Thyroid function tests (TSH, FT3, FT4) and logistic regression analysis performed.

Main Results:

• The MTHFR C677T polymorphism showed a significant association with SCH (P<0.05).
• The C677T T allele, abnormal pre-pregnancy BMI, and anemia history were identified as risk factors for SCH.
• No significant association was found for the MTHFR A1298C polymorphism.

Conclusions:

• MTHFR C677T polymorphism is a potential risk factor for SCH in early pregnancy.
• Abnormal pre-pregnancy BMI and anemia history are also associated with increased SCH risk.
• Further prospective studies are needed to confirm these findings and guide clinical practice.