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Updated: Jun 25, 2026

Cell-free Biochemical Fluorometric Enzymatic Assay for High-throughput Measurement of Lipid Peroxidation in High Density Lipoprotein
07:29

Cell-free Biochemical Fluorometric Enzymatic Assay for High-throughput Measurement of Lipid Peroxidation in High Density Lipoprotein

Published on: October 12, 2017

Elevated lipoprotein(a) levels are associated with adverse left ventricular geometric remodeling in non-diabetic

Tolga Kunak1, Ayşegül Ülgen Kunak2, İbrahim Başarici1

  • 1Department of Cardiology, Akdeniz University, Faculty of Medicine, Antalya, Turkey.

Blood Pressure
|June 24, 2026
PubMed

Insights

Elevated Lipoprotein(a) [Lp(a)] levels are linked to adverse left ventricular (LV) remodeling, specifically concentric hypertrophy, in hypertensive patients. Lp(a) assessment aids cardiovascular risk stratification.

Area of Science:

  • Cardiology
  • Hypertension Research
  • Lipid Metabolism

Background:

  • Lipoprotein(a) [Lp(a)] is a known cardiovascular risk factor.
  • Its association with left ventricular (LV) geometric remodeling in hypertension is not well-defined.
  • Essential hypertension and elevated Lp(a) are significant cardiovascular concerns.

Purpose of the Study:

  • To investigate the association between serum Lp(a) levels and LV geometry.
  • To examine LV remodeling patterns in non-diabetic patients with essential hypertension.
  • To determine if Lp(a) is an independent predictor of LV geometric changes.

Main Methods:

  • Cross-sectional observational study of 110 non-diabetic hypertensive patients.
  • Patients grouped by low (<50 mg/dL) and elevated (≥50 mg/dL) Lp(a) levels.
  • Echocardiography assessed LV mass index (LVMI) and geometry; regression analyses identified associations.

Main Results:

  • Elevated Lp(a) group showed significantly higher LVMI (139.6 vs. 117.6 g/m², p<0.001).
  • Concentric LV hypertrophy was more prevalent in the elevated Lp(a) group (55.0% vs. 20.0%, p=0.001).
  • Lp(a) was independently associated with LVMI and odds of concentric LV hypertrophy.

Conclusions:

  • Elevated serum Lp(a) is independently linked to adverse LV geometric remodeling and concentric hypertrophy in hypertensive patients.
  • Lp(a) assessment may enhance cardiovascular risk stratification.
  • Identifying high-risk hypertensive patients for target organ damage is crucial.
Abstract

Keywords:
Lipoprotein(a)cardiac remodellingechocardiographyhypertensionleft ventricular geometryleft ventricular hypertrophy

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