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Updated: Jun 26, 2026

Spectrophotometric Screening for Potential Inhibitors of Cytosolic Glutathione S-Transferases
Published on: October 10, 2020
[Advances in glutathione biosynthesis and industrialization]
Chaoping Lin1,2, Xu Yang1,2, Yang Chen1,2
1Zhejiang Key Laboratory of Bioorganic Synthesis, College of Biotechnology and Bioengineering, Zhejiang University of Technology, Hangzhou 310014, Zhejiang, China.
Glutathione, a vital antioxidant and detoxifier, is crucial in pharmaceuticals, food, and cosmetics. This review explores its biosynthesis, industrial production, and emerging green manufacturing technologies to facilitate industry upgrades.
Area of Science:
- Biotechnology
- Biochemistry
- Industrial Microbiology
Background:
- Glutathione is a ubiquitous thiol tripeptide with significant antioxidant and detoxifying properties.
- It finds extensive applications across pharmaceuticals, food, cosmetics, and feed additives.
- The biomanufacturing sector is increasingly focusing on the industrial production of glutathione.
Purpose of the Study:
- To review the physiological functions and diverse application fields of glutathione.
- To summarize research progress in glutathione biosynthesis and industrialization.
- To explore emerging technologies for glutathione production and its commercial development.
Main Methods:
- Literature review of glutathione biosynthesis pathways.
- Analysis of current industrial production processes.
- Examination of emerging green biomanufacturing technologies.
- Review of commercialization strategies and market trends.
Main Results:
- Glutathione's antioxidant and detoxifying roles are well-established, supporting its wide industrial use.
- Significant advancements have been made in understanding glutathione biosynthesis.
- Novel green biomanufacturing techniques are emerging for more sustainable production.
- The commercial landscape for glutathione is evolving with technological progress.
Conclusions:
- Industrial upgrading of glutathione production is a key research area, driven by green biomanufacturing.
- Further development in biosynthesis and novel production processes is essential.
- Optimizing commercial strategies will support the sustainable growth of the glutathione market.
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