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Related Concept Videos

Production of Pharmaceuticals01:30

Production of Pharmaceuticals

Industrial insulin production uses genetically engineered E. coli expressing a proinsulin gene controlled by a tryptophan promoter and containing a methionine linker for later cleavage. The cells also carry ampicillin resistance for selective growth. Seed cultures are stored at −80 °C and production begins by thawing a small amount to inoculate starter cultures, which are progressively scaled to a 50,000-L bioreactor. In the bioreactor, E. coli grow in nutrient-rich media under sterile, tightly...

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The Development of a Syringe-Based Insulin Applicator Using a Biodesign-Based Methodology.

Alejandro A Salinas-Aguilar1, Sebastian Arriaga-Marin1, Carlos A Perez-Ramirez1

  • 1Tequexquite, Centro de Investigación y Desarrollo Tecnológico para la Accesibilidad e Innovación Social, Facultad de Ingeniería, Universidad Autónoma de Querétaro, Campus Aeropuerto, Carretera a Chichimequillas S/N, Ejido Bolaños, Querétaro 76140, Mexico.

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|June 25, 2026
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Summary
This summary is machine-generated.

A novel insulin applicator design simplifies diabetes management by ensuring correct subcutaneous injection without extensive user training. This biomimetic device aids in creating skin folds and guiding needles for effective insulin delivery.

Keywords:
biodesign methodologyindustrial designinsuline applicator

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Area of Science:

  • Biomedical Engineering
  • Medical Device Design

Background:

  • Effective diabetes management requires proper insulin administration techniques.
  • Traditional methods often necessitate specialized training for correct subcutaneous injection.
  • There is a need for user-friendly insulin applicators that simplify the administration process.

Purpose of the Study:

  • To design an insulin applicator using a biodesign and biomimetic approach.
  • To create a device that assists users in forming stable skin folds and guiding needle insertion.
  • To develop an applicator that minimizes the need for extensive user training.

Main Methods:

  • A three-step design approach incorporating biodesign and biomimetic principles.
  • Computational Fluid Dynamics (CFD) to ensure laminar insulin flow and assess mechanical properties.
  • Finite Element Analysis (FEA) to test device strength and deformation under stress.
  • Infrared thermography to validate the location of force generation during skin fold creation.

Main Results:

  • The designed applicator facilitates correct insulin delivery without requiring exhaustive training.
  • CFD analysis confirmed a laminar insulin flow, avoiding complications from turbulent flow.
  • FEA results demonstrated the device's structural integrity, handling folding stresses without excessive deformation.
  • Infrared thermography validated that the device operates within the desired physical zone for effective injection.

Conclusions:

  • The biodesign and biomimetic approach successfully yielded an intuitive insulin applicator.
  • The device design is validated through CFD, FEA, and infrared thermography, confirming its functional efficacy and safety.
  • This innovative applicator can improve patient adherence and outcomes in diabetes management by simplifying insulin injection procedures.