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Related Experiment Video

Updated: Jun 27, 2026

Unilateral Lung Volume Analysis Using Micro-CT for Enhanced Assessment of Pulmonary Fibrosis in Preclinical Models
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Unilateral Lung Volume Analysis Using Micro-CT for Enhanced Assessment of Pulmonary Fibrosis in Preclinical Models

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Antibiotic-Induced Pulmonary Fibrosis: National Database Analysis.

Olga Butranova1, Yury Kustov1, Anna Abramova1

  • 1Department of General and Clinical Pharmacology, Peoples' Friendship University of Russia Named After Patrice Lumumba (RUDN), 6 Miklukho-Maklaya St., 117198 Moscow, Russia.

Biomedicines
|June 26, 2026
PubMed
Summary
This summary is machine-generated.

Cefuroxime shows a strong safety signal for drug-induced pulmonary fibrosis (DIPF). Further research is needed to confirm causality, as other antibacterials also warrant attention.

Keywords:
antibioticsazithromycincefuroximedoxycyclinelevofloxacinpulmonary fibrosistrimethoprim-sulfamethoxazole

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Oropharyngeal Administration of Bleomycin in the Murine Model of Pulmonary Fibrosis
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Oropharyngeal Administration of Bleomycin in the Murine Model of Pulmonary Fibrosis

Published on: May 9, 2025

Area of Science:

  • Pharmacovigilance
  • Pulmonary Medicine
  • Drug Safety

Background:

  • Pulmonary fibrosis (PF) is a significant global health concern.
  • Drug-induced lung injury (DILI) is a key factor in PF development.
  • Antimicrobial agents are among the drugs implicated in DILI.

Purpose of the Study:

  • To analyze antibacterial agents associated with drug-induced pulmonary fibrosis (DIPF).
  • To evaluate safety signals for DIPF using spontaneous reports.
  • To calculate reporting odds ratio (ROR) and proportional reporting ratio (PRR).

Main Methods:

  • Retrospective, descriptive pharmacoepidemiological analysis.
  • Utilized spontaneous reports from the Russian National Pharmacovigilance database (AIS).
  • Analyzed data from April 2019 to March 2025.

Main Results:

  • Identified 130 spontaneous reports of DIPF linked to antibacterials.
  • Cefuroxime demonstrated the strongest association with DIPF (PRR=15.11, ROR=15.31).
  • Other implicated antibacterials included sulfamethoxazole, azithromycin, levofloxacin, and doxycycline.

Conclusions:

  • Cefuroxime presents a robust, unexpected safety signal for DIPF.
  • Findings suggest potential protopathic bias or context-dependent effects.
  • Further prospective studies are required to validate these safety signals and explore causality.