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Related Experiment Video

Updated: Jun 27, 2026

Analyzing Ex Vivo Metabolic Flux in Splenic and Cardiac Macrophages and Bone Marrow Monocytes
06:26

Analyzing Ex Vivo Metabolic Flux in Splenic and Cardiac Macrophages and Bone Marrow Monocytes

Published on: March 28, 2025

Metabolic Reprogramming-Driven Cardiovascular Immune Damage: From Glyco-Lipotoxicity and Epigenetic Memory to

Zijin Sun1, Yongchao Liu2, Kai Wang1

  • 1School of Traditional Chinese Medicine, Beijing University of Chinese Medicine, Beijing 102488, China.

International Journal of Molecular Sciences
|June 26, 2026
PubMed
Summary

Metabolic reprogramming, driven by glyco-lipotoxicity, fuels persistent inflammation and cardiovascular disease (CVD) by altering immune cell metabolism and epigenetic memory. Targeting this immunometabolic axis offers new strategies for cardiovascular protection.

Keywords:
NLRP3 inflammasomecross-organ communicationepigenetic remodellingglyco-lipotoxicitymetabolic reprogrammingtrained immunity

Related Experiment Videos

Last Updated: Jun 27, 2026

Analyzing Ex Vivo Metabolic Flux in Splenic and Cardiac Macrophages and Bone Marrow Monocytes
06:26

Analyzing Ex Vivo Metabolic Flux in Splenic and Cardiac Macrophages and Bone Marrow Monocytes

Published on: March 28, 2025

Area of Science:

  • Immunometabolism
  • Cardiovascular Biology
  • Epigenetics

Background:

  • Cardiovascular disease (CVD) is a leading cause of death, with persistent inflammation a key risk factor.
  • Immune cell metabolic reprogramming drives cardiovascular immune injury.
  • Glyco-lipotoxicity and metabolic changes contribute to sustained inflammation.

Purpose of the Study:

  • To propose a unifying framework linking metabolic reprogramming to cardiovascular immune injury.
  • To explore the role of glyco-lipotoxicity, trained immunity, and organ crosstalk in CVD.
  • To summarize therapeutic strategies targeting the metabolic-epigenetic axis for CVD prevention.

Main Methods:

  • Review of emerging evidence on immunometabolism in CVD.
  • Analysis of metabolic pathways (glycolysis, oxidative phosphorylation) in immune cells.
  • Examination of epigenetic modifications and trained immunity.
  • Integration of organ crosstalk mechanisms (heart-adipose, gut-heart, cardio-hematopoietic axes).

Main Results:

  • Glyco-lipotoxicity triggers mitochondrial dysfunction, oxidative stress, and inflammasome activation.
  • Hyperglycaemia and dyslipidaemia promote pro-inflammatory immune cell phenotypes.
  • Metabolic intermediates drive epigenetic changes, establishing trained immunity and metabolic memory.
  • Persistent immunometabolic imprints amplify inflammation and accelerate vascular/myocardial remodeling.
  • Cross-organ communication networks propagate inflammatory processes.

Conclusions:

  • Metabolic reprogramming is a central mechanism in CVD pathogenesis.
  • Trained immunity and metabolic memory contribute to persistent inflammation.
  • Targeting the metabolic-epigenetic axis and organ crosstalk offers novel therapeutic avenues for CVD.
  • Precision strategies focusing on immunometabolism hold promise for cardiovascular protection.