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Related Experiment Video

Updated: Jun 27, 2026

A Gut-on-a-Chip Model to Study the Gut Microbiome-Nervous System Axis
09:18

A Gut-on-a-Chip Model to Study the Gut Microbiome-Nervous System Axis

Published on: July 28, 2023

Decoding the Gut-Fat-Heart Axis: From Molecular Communication Networks to Clinical Translation Strategies.

Zijin Sun1, Wei Shao1, Haojia Zhang1

  • 1School of Traditional Chinese Medicine, Beijing University of Chinese Medicine, Beijing 102488, China.

International Journal of Molecular Sciences
|June 26, 2026
PubMed
Summary

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Gut-Brain Axis01:22

Gut-Brain Axis

The gut–brain axis is a bidirectional communication system that connects the gastrointestinal tract and the brain. This interaction is mediated through multiple pathways, including the vagus nerve, hormonal signals, immune responses, and chemical messengers produced by gut microbes.Microbial Contributions to Brain FunctionGut microbiota contributes significantly to brain function by producing neuroactive compounds. These include neuroactive compounds that influence neurotransmitters such as...

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The gut-fat-heart axis reveals how gut microbes influence cardiovascular health. Understanding this axis offers new strategies for managing metabolic and heart diseases by targeting microbial metabolites.

Area of Science:

  • Microbiology
  • Cardiovascular Medicine
  • Metabolic Science

Background:

  • Cardiovascular disease (CVD) management is shifting from lipid-focused to holistic metabolic approaches.
  • The gut-fat-heart axis integrates neural, endocrine, and immunometabolic signals for lipid homeostasis.
  • Gut microbiota acts as a metabolic organ, producing bioactive metabolites that impact host health.

Purpose of the Study:

  • To systematically explore the gut-fat-heart axis and its role in cardiovascular health.
  • To elucidate how microbial metabolites and communication networks regulate systemic lipid metabolism.
  • To outline clinical strategies for managing cardiovascular-kidney-metabolic (CKM) syndrome.

Main Methods:

  • Review of physiological and pathological mechanisms of the gut-fat-heart axis.
Keywords:
cardiovascular diseaseclinical translation strategiesgut–fat–heart axisholistic metabolic perspectivelipotoxicitytrimethylamine N-oxide

Related Experiment Videos

Last Updated: Jun 27, 2026

A Gut-on-a-Chip Model to Study the Gut Microbiome-Nervous System Axis
09:18

A Gut-on-a-Chip Model to Study the Gut Microbiome-Nervous System Axis

Published on: July 28, 2023

  • Analysis of microbial metabolites like SCFAs, bile acids, TMAO, and LPS.
  • Examination of signaling pathways including FXR-FGF15/19, GLP-1, vagus nerve, and G protein-coupled receptors.

    • Main Results:

    • Microbial products (SCFAs, bile acids) regulate energy balance and lipid synthesis.
    • Gut hormones (GLP-1) and neural pathways control lipid clearance and feeding.
    • Dysbiosis leads to harmful metabolites (TMAO, LPS), promoting lipotoxicity, inflammation, and atherosclerosis progression.

    Conclusions:

    • The gut-fat-heart axis is crucial for understanding and treating CVD and metabolic syndrome.
    • Targeting microbial metabolites and pathways offers novel therapeutic strategies.
    • Developing TMA lyase inhibitors, probiotics, and phytochemicals can reshape the gut microbiota for CKM syndrome management.