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Atrial Fibrillation in Infiltrative Cardiomyopathies: From Atrial Cardiomyopathy Imaging to Targeted Management-A
Matteo Brusamolino1, Francesco Catagnano1, Maria Lo Monaco1
1Department of Cardiology, Humanitas Gavazzeni Hospital, Via Gavazzeni 21, 24125 Bergamo, Italy.
Medicina (Kaunas, Lithuania)
|June 26, 2026
Summary
Atrial fibrillation is common in infiltrative cardiomyopathies due to atrial remodeling. Multimodal cardiac imaging helps evaluate this atrial cardiomyopathy, guiding clinical management.
Area of Science:
- Cardiology
- Cardiovascular Imaging
- Electrophysiology
Background:
- Infiltrative cardiomyopathies lead to heart failure via myocardial substrate accumulation.
- Atrial fibrillation is a frequent complication, increasing morbidity and mortality.
- Atrial cardiomyopathy, involving structural and electrical remodeling, links infiltrative disease to atrial fibrillation.
Purpose of the Study:
- To review current evidence on atrial fibrillation in infiltrative cardiomyopathies.
- To highlight the role of non-invasive multimodal imaging in assessing atrial cardiomyopathy.
- To explore how imaging insights can impact clinical management.
Main Methods:
- Literature review of contemporary evidence.
- Focus on multi-modality cardiac imaging techniques.
- Analysis of pathophysiological mechanisms linking myocardial infiltration to atrial fibrillation.
Main Results:
- Atrial cardiomyopathy is a key substrate for atrial fibrillation in these conditions.
- Non-invasive imaging provides mechanistic insights into atrial remodeling.
- Imaging facilitates comprehensive assessment of the atrial substrate.
Conclusions:
- Atrial cardiomyopathy is central to atrial fibrillation development in infiltrative cardiomyopathies.
- Multimodal cardiac imaging is crucial for evaluating atrial cardiomyopathy.
- Imaging-guided assessment may improve clinical outcomes for patients.
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