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Updated: Jun 27, 2026
10:24
Assessing the Viability of a Synthetic Bacterial Consortium on the In Vitro Gut Host-microbe Interface
Published on: July 4, 2018
Functional and Psychobiotic Potential of a Food-Derived Multi-Strain Lactic Acid Bacteria Consortium: An In Vitro
Wioletta Mosiej1, Marcin Kruk1, Tomasz Królikowski1
1Institute of Human Nutrition Sciences, Warsaw University of Life Sciences-SGGW, Nowoursynowska 159c, 02-776 Warsaw, Poland.
Nutrients
|June 26, 2026
Summary
A multi-strain lactic acid bacteria (LAB) consortium from fermented foods shows promise as a psychobiotic. This consortium effectively modulated the gut microbiota and enhanced beneficial metabolites, supporting the microbiota-gut-brain axis.
Area of Science:
- Microbiology
- Neuroscience
- Gastroenterology
Background:
- The microbiota-gut-brain axis (MGBA) is crucial for cognitive function.
- Psychobiotics are a potential therapeutic strategy for neurodegenerative diseases.
- Lactic acid bacteria (LAB) from fermented foods are potential psychobiotic candidates.
Purpose of the Study:
- To evaluate the functional and psychobiotic potential of three LAB strains.
- To assess LAB strains as monocultures and a multi-strain consortium (MIX).
- To investigate the efficacy of a LAB consortium for MGBA modulation.
Main Methods:
- Screening of individual strains and MIX for mucin adhesion and digestive stability.
- Amino acid profiling of LAB strains and MIX.
- Long-term evaluation of LAB MIX in a dynamic gastrointestinal model (SHIME®) using Alzheimer's disease patient microbiota.
Main Results:
- The LAB MIX exhibited high stability and mucoadhesive properties.
- The consortium displayed a unique metabolic signature with enhanced functional effects.
- In the SHIME® model, the MIX altered gut microbiota composition, increasing lactobacilli and beneficial metabolites like GABA precursors.
Conclusions:
- The evaluated LAB consortium is a promising psychobiotic candidate.
- The consortium demonstrates potential for modulating the microbiota-gut-brain axis.
- Further in vivo and clinical studies are needed to confirm therapeutic efficacy.
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