[Sex, gender, and evidence-based medicine : how to close research gaps ?]

Research continues to inadequately integrate gender and diversity, reflecting the longstanding model in which the male body has been considered the universal standard. To address these gaps, initiatives like the SAGER (Sex And Gender Equity in Research) and SAGER-swissethics guidelines have emerged, to encourage the integration of sex and gender into research, from the design to the dissemination of results. Clinical guidelines rarely include sex- or gender-specific recommendations. It is unclear whether this lack reflects the absence of differences or, conversely, a lack of data to establish specific differences. While awaiting an update in the data, clinicians are invited to critically read the literature, adjust dosages to body compositions, and value patients' experiences to ensure equitable care.