Related Experiment Video
Updated: Jun 28, 2026

A Platform of Anti-biofilm Assays Suited to the Exploration of Natural Compound Libraries
Published on: December 27, 2016
Construction and application of a multifunctional material intelligent screening platform for food-derived bioactive
Xiaoyang Zhang1, Shuo Sun1, Changhao Jia1
1College of Pharmaceutical Engineering of Traditional Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China.
Abstract:
This study aimed to construct an intelligent screening platform for co-amorphous materials (CAMs) based on machine learning and large language models to improve the development efficiency of co-amorphous systems for food-derived bioactive compounds. The platform enabled formation-probability prediction and interpretable analysis, thereby supporting the efficient development of CAMs. Guided by this platform, three novel myricetin-based CAMs were successfully developed. Solid-state characterization confirms the successful amorphization of the three systems. Multiscale simulations reveal that multi-site noncovalent interactions are the main driving forces for amorphization. The CAMs markedly improved myricetin wettability and simulated digestive release. The CAMs enhanced antioxidant activity, with the lowest DPPH and ABTS IC50 values reaching 4.21 and 1.86 μM, respectively. CAMs increased the inhibition zone diameters against S. aureus and E. coli to approximately 1.14-1.26-fold and 2.12-3.15-fold those of free myricetin, respectively. Preservation studies further show that the three materials effectively extend the shelf life of tomatoes.
More Related Videos
Related Concept Videos
Bioavailability Enhancement: Drug Stability Enhancement and GI Retention
Bioavailability Enhancement: Drug Solubility Enhancement
Bioavailability Enhancement: Determination and Conceptual Approaches in Overcoming Bioavailability Problems

