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Published on: May 6, 2014
Is Ozone Therapy Effective in Preventing and Treating Alveolar Osteitis? A Systematic Review.
Vitolante Pezzella1, Alessandro Cuozzo2, Andrea Blasi3
1PhD Student, Department of Periodontology, School of Dental Medicine, University of Naples Federico II, Naples, Italy.
Summary
Ozone therapy shows potential for preventing alveolar osteitis (AO) after tooth extraction, reducing pain and complications. However, more high-quality research is needed to confirm its effectiveness and optimal use.
Area of Science:
- Dentistry
- Oral Surgery
- Regenerative Medicine
Background:
- Alveolar osteitis (AO) is a common, painful complication after tooth extraction.
- Current prevention strategies for AO have limited success, necessitating further research.
- AO negatively impacts patient quality of life and requires extensive follow-up care.
Purpose of the Study:
- To systematically review the clinical effectiveness of ozone therapy for preventing and treating alveolar osteitis (AO) in adults.
- To evaluate different ozone formulations including gaseous ozone, ozonated water, and ozonated oils/gels.
- To assess outcomes such as AO frequency, postoperative pain, analgesic use, and healing.
Main Methods:
- A comprehensive literature search was performed across major scientific databases up to April 2025.
- Included studies were randomized controlled trials (RCTs), controlled trials (CTs), and prospective clinical studies.
- Eight studies met the inclusion criteria after screening 55 records, with two independent reviewers involved.
Main Results:
- Preventive use of gaseous ozone and ozonated sunflower oil gel showed reduced AO frequency and pain post-extraction.
- Evidence for ozonated water in AO prevention was conflicting and inconsistent.
- One trial indicated promising therapeutic effects of ozone combined with growth factors for established AO.
Conclusions:
- Ozone therapy may be a beneficial adjunct for reducing AO incidence and improving outcomes after third molar surgery.
- Current evidence is limited and heterogeneous, highlighting the need for further robust RCTs.
- More research is required to establish definitive clinical effectiveness and optimal ozone delivery protocols for AO.
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