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Reply to "Methodological Challenges in Interpreting SAA-Defined Imaging Subgroups in Parkinson's Disease"

Shannon Y Chiu1, Wei-En Wang2, Robin Chen2

  • 1Department of Neurology, Mayo Clinic College of Medicine, Scottsdale, Arizona, USA.

Annals of Neurology
|June 29, 2026
PubMed
Summary

No abstract available in PubMed .

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Parkinson Disease ll: Pathophysiology01:24

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Parkinson disease (PD) is a progressive neurodegenerative disorder primarily affecting movement, with additional non-motor features. Its pathophysiology involves complex interactions among genetic susceptibility, environmental exposures, and cellular dysfunction, including dopaminergic neuron loss, protein aggregation, and mitochondrial impairment.Selective NeurodegenerationA key feature is the degeneration of dopaminergic neurons in the substantia nigra pars compacta, leading to reduced...

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