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Updated: Jul 1, 2026

Examination of Pyroptosis by Flow Cytometry

Examination of Pyroptosis by Flow Cytometry

Published on: May 31, 2024

Gasdermin E: Bridging Pyroptosis, Immunity, and Disease Pathogenesis Toward Precision Intervention.

Ping Wang¹, Chuandan Wan², Yeqiong Xu²

¹School of Basic Medical Sciences, Wannan Medical University, Wuhu, 241002, China.

The Protein Journal

|June 30, 2026

Summary

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Microorganisms play a fundamental role in vaccine development, gene therapy, and therapeutic production. Their biological properties are harnessed to advance medicine and public health. Beyond immunization, microorganisms contribute to gut health, antibiotic synthesis, and genetic disease treatment.Live Attenuated and Inactivated VaccinesLive attenuated vaccines, such as the measles, mumps, and rubella (MMR) vaccine, utilize weakened forms of pathogens to closely resemble natural infections.

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Gasdermin E (GSDME) regulates immune responses and cell death, acting as a tumor suppressor or pro-inflammatory mediator. Understanding its dual roles is key for developing targeted therapies in cancer and inflammatory diseases.

Area of Science:

Immunology
Cell Biology
Molecular Medicine

Background:

Gasdermin E (GSDME) is a key pyroptosis executor involved in immune responses.
Initially identified as a tumor suppressor (DFNA5), GSDME has complex roles in disease.

Purpose of the Study:

To review GSDME's structure, activation pathways (canonical and non-canonical), and dual functions.
To evaluate GSDME's potential as a biomarker and therapeutic target across diseases.
To analyze strategies for modulating GSDME activity for therapeutic benefit.

Main Methods:

Literature review synthesizing current research on GSDME.
Systematic dissection of GSDME's functions in cancer, inflammation, neurodegeneration, and organ injury.
Critical analysis of pharmacological strategies targeting GSDME.

Keywords:

Biomarker Caspase-3 GSDME Immune regulation Nanomedicine Pyroptosis Targeted therapy

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Last Updated: Jul 1, 2026

Examination of Pyroptosis by Flow Cytometry

Examination of Pyroptosis by Flow Cytometry

Published on: May 31, 2024

Main Results:

GSDME activation via caspase-3 cleavage triggers pro-inflammatory pyroptosis.
GSDME exhibits context-dependent dual roles, acting as a tumor suppressor or promoting inflammation.
Emerging non-canonical pathways and diverse therapeutic strategies are being explored.

Conclusions:

GSDME is a critical regulator of immunity and cell death with significant therapeutic potential.
Targeting GSDME offers opportunities for precision medicine in oncology and inflammatory diseases.
Further research is needed for clinical translation of GSDME-targeted therapies.