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Utility of a Simplified Irradiator for Photosensitivity Testing in Head and Neck Photoimmunotherapy
Tatsuya Yamakura1, Isaku Okamoto2, Takuro Okada2
1Department of Otorhinolaryngology, Head and Neck Surgery, Tokyo Medical University, Tokyo, Japan yamakura.tatsuya.2r@tokyo-med.ac.jp.
Background/Aim:
Head and neck photoimmunotherapy (HN-PIT) using cetuximab sarotalocan sodium requires post-treatment assessment for photosensitivity, but tests using direct sunlight are affected by weather and lack standardization. This study evaluated a simplified artificial irradiator for more consistent light irradiation testing.
Patients And Methods:
This single-center retrospective study analyzed 16 HN-PIT treatments in 8 patients with unresectable locally advanced or recurrent head and neck cancer. On days 6-7 post-treatment, patients underwent both direct sunlight exposure and a simple irradiation test using a FLASH-PAK projector equipped with an R-60 filter to evaluate reactions around the clinically relevant 690 nm wavelength. Erythema and edema were assessed on the day of the test and 1 month later.
Results:
No photosensitivity reactions occurred with either method, nor were delayed reactions observed.
Conclusion:
The simplified irradiator allows standardized, weather-independent photosensitivity testing after HN-PIT, although further studies are needed to confirm sensitivity and long-term reliability.
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