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Related Concept Videos

Mitral Valve Prolapse I: Introduction01:27

Mitral Valve Prolapse I: Introduction

IntroductionThe mitral valve, one of the heart's four valves, regulates blood flow. These valves have flaps that open and close to direct blood properly through the heart and body. During each heartbeat, the flaps open for blood to pass through and seal shut to prevent backflow. Specifically, the mitral valve opens to allow blood flow from the heart's upper left chamber to the lower left chamber. It then closes securely as the lower left chamber contracts to pump blood to the body, preventing...
Mitral Stenosis II: Clinical features and Diagnostic Tests01:23

Mitral Stenosis II: Clinical features and Diagnostic Tests

Mitral stenosis is a heart condition in which the mitral valve, which allows blood to flow from the left atrium to the left ventricle, becomes narrowed or stenotic. This narrowing hinders blood flow and leads to clinical symptoms requiring specific medical evaluations and management strategies. The following overview outlines the clinical symptoms, assessments, diagnostic findings, prevention methods, and treatments for mitral stenosis.Clinical ManifestationsDyspnea (shortness of breath): This...
Mitral Valve Prolapse II: Assessment and Management01:22

Mitral Valve Prolapse II: Assessment and Management

IntroductionA range of clinical features characterizes Mitral Valve Prolapse (MVP), but it is important to note that many individuals with MVP are asymptomatic and may remain so throughout their lives. For those who do exhibit symptoms, the following are the key clinical features:Palpitations: This is a common symptom where individuals feel an irregular or rapid heartbeat. Palpitations in MVP are often due to arrhythmias such as premature ventricular contractions or supraventricular tachycardia.

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Related Experiment Video

Updated: Jul 2, 2026

Anatomically Realistic Neonatal Heart Model for Use in Neonatal Patient Simulators
10:05

Anatomically Realistic Neonatal Heart Model for Use in Neonatal Patient Simulators

Published on: February 5, 2019

Physically validated mitral valve models for surgical simulation: Bridging anatomy, pathology, and practice.

Patrick Carnahan1, Charles Yuan1, John Moore1

  • 1Imaging Laboratories, Robarts Research Institute, Western University, London, Ontario, Canada.

JTCVS Open
|July 1, 2026
PubMed
Summary

A new mathematical model accurately simulates mitral valve geometry and function. This tool offers a standardized platform for surgical training and testing repair techniques for mitral valve disease.

Keywords:
mathematical modelmitral valvemitral valve repairmitral valve surgerysimulationtraining

Related Experiment Videos

Last Updated: Jul 2, 2026

Anatomically Realistic Neonatal Heart Model for Use in Neonatal Patient Simulators
10:05

Anatomically Realistic Neonatal Heart Model for Use in Neonatal Patient Simulators

Published on: February 5, 2019

Area of Science:

  • Cardiovascular Research
  • Biomedical Engineering
  • Surgical Simulation

Background:

  • Mitral valve repair effectiveness is operator-dependent due to a lack of standardized training.
  • Current simulation platforms often rely on biological tissue, limiting reproducibility.

Purpose of the Study:

  • To develop and validate a simplified, parametric mathematical model of the mitral valve apparatus.
  • To assess the model's ability to recreate healthy and pathological mitral valve geometry and hemodynamics.

Main Methods:

  • A parametric mathematical framework defined the 3D mitral annulus and leaflet architecture using geometric coefficients.
  • Five silicone valve replicas (2 healthy, 3 prolapse variants) were manufactured.
  • Models were tested in a dynamic pulse duplicator and assessed using cardiac ultrasound.

Main Results:

  • Physical valve replicas accurately matched expected anatomical ranges.
  • Healthy models showed competent function without regurgitation.
  • Pathological models consistently exhibited mitral regurgitation predictable from geometric inputs.

Conclusions:

  • A physically validated, configurable mathematical model links geometric parameters to mitral valve function.
  • This approach offers a standardized, reproducible, and customizable platform for surgical training and testing repair techniques.
  • The model is suitable for studying segmental mitral valve disease.