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Persistent Subretinal Fluid in a Case With Central Serous Chorioretinopathy and Progressive Retinal Changes: An
Ryoh Funatsu1, Naohisa Mihara1, Hiroto Terasaki1
1Department of Ophthalmology, Graduate School of Medical and Dental Sciences, Kagoshima University, Kagoshima, Japan, kagoshima-u.ac.jp.
Case Reports in Ophthalmological Medicine
|July 1, 2026
Summary
Central serous chorioretinopathy (CSC) with persistent serous retinal detachment can cause rapid vision loss and retinal damage. Long-term monitoring reveals progressive outer nuclear layer thinning and increased photoreceptor reflectivity.
Area of Science:
- Ophthalmology
- Retinal Diseases
- Medical Imaging
Background:
- Central serous chorioretinopathy (CSC) is characterized by serous detachment of the neurosensory retina.
- Persistent CSC can lead to significant visual impairment and structural retinal changes.
Purpose of the Study:
- To document the longitudinal changes in visual acuity and retinal structure in a patient with CSC and persistent serous retinal detachment over 18 months.
Main Methods:
- Case report of a male patient in his 40s diagnosed with CSC.
- Best-corrected visual acuity (BCVA) and optical coherence tomography (OCT) were used for monitoring.
- Fluorescein angiography was performed for diagnosis.
Main Results:
- The patient experienced a decline in BCVA from 20/25 to 20/200 over 18 months.
- Optical coherence tomography showed progressive thinning of the outer nuclear layer (ONL) from 86µm to 46µm.
- Increased photoreceptor reflectivity and intraretinal hyperreflective foci were observed.
Conclusions:
- Persistent serous retinal detachment in CSC is associated with a rapid decrease in BCVA.
- Chronic CSC leads to structural damage, including ONL thinning and altered photoreceptor reflectivity.
