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Updated: Jul 4, 2026

Detection and Monitoring of Tumor Associated Circulating DNA in Patient Biofluids
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Detection and Monitoring of Tumor Associated Circulating DNA in Patient Biofluids

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A Data-Management Tool for Reactive Sample Handling in Molecular Blood Donor Screening.

Eleftheria Orfanidi1,2, Joseph Liaskos1, Emmanouil Zoulias1

  • 1Health Informatics Laboratory, Faculty of Nursing, School of Health Sciences, National and Kapodistrian University of Athens, Athens, Greece.

Studies in Health Technology and Informatics
|July 3, 2026
PubMed
Summary

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A new data management application improves handling of reactive blood samples during molecular screening. This tool enhances data integrity and efficiency in blood donation services, ensuring transfusion safety.

Area of Science:

  • Transfusion Medicine
  • Biotechnology
  • Health Informatics

Background:

  • Blood transfusion safety is paramount, relying on accurate interpretation of serological and molecular assays.
  • Effective data management is crucial for handling initially reactive samples in molecular screening.
  • Existing workflows may lack the precision and traceability needed for complex reactive cases.

Purpose of the Study:

  • To develop and evaluate a data-management application for handling initially reactive blood donor samples.
  • To assess the application's performance and user satisfaction in a real-world laboratory setting.
  • To compare the new system's advantages against the existing data management workflow.

Main Methods:

  • Implementation of a novel data-management system in the Molecular Screening Laboratory of the Hellenic National Blood Transfusion Center.
Keywords:
Blood DonorsBlood SafetyData ManagementWorkflow

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  • Description of the existing data management workflow for comparative analysis.
  • Pilot evaluation involving a focus group of laboratory staff to assess user satisfaction and system performance.
  • Main Results:

    • The application demonstrated high user satisfaction and smooth performance during pilot testing.
    • Key advantages included enhanced data-integrity protections and functional improvements over the existing workflow.
    • Scalability limitations were identified as an area for future development.

    Conclusions:

    • The developed data-management tool effectively strengthens reactive sample-handling processes.
    • The application supports more efficient and reliable data management in blood donation services.
    • Further improvements are recommended, particularly regarding system scalability.