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Precision Medicine in Rural Settings: Clinician Perspectives on Clinician-Ordered Genetic Testing
Anne C Madeo1, Kimberly A Kaphingst2,3, Melissa Yack2
1Department of Population Health Sciences, University of Utah, 295 Chipeta Way, Williams Building, Suite 16, University of Utah, Salt Lake City, UT, 84108, USA.
Research Square
|July 3, 2026
Summary
Rural clinicians find genetic testing acceptable and appropriate, especially when results impact patient care. However, they need more knowledge and support for selecting and interpreting genetic tests in their practice.
Area of Science:
- Genetics
- Rural Health
- Healthcare Implementation Science
Background:
- Limited access to genetic specialists in rural areas.
- Understanding rural clinicians' perspectives is crucial for integrating genetic testing into primary care.
- Previous research highlights a scarcity of specialty care providers in non-urban settings.
Purpose of the Study:
- To explore rural clinicians' perceptions of genetic testing.
- To identify barriers and facilitators for genetic testing adoption in rural healthcare settings.
- To understand how genetic testing acceptability and appropriateness are influenced by clinician factors.
Main Methods:
- Semi-structured interviews with 19 rural clinicians in the Mountain West.
- Thematic analysis using a hybrid deductive-inductive approach.
- Frameworks used: Practical, Robust Implementation and Sustainability Model (PRISM) and Implementation Outcomes Framework (IOF).
Main Results:
- Rural clinicians found genetic testing discussions acceptable and appropriate.
- Clinical actionability of genetic test results significantly influenced acceptability.
- Clinicians expressed concerns regarding test selection, interpretation, and lack of routine integration into workflows.
Conclusions:
- Genetic testing is perceived positively by rural clinicians when clinically actionable.
- Gaps in knowledge and reliance on specialist referrals hinder routine genetic testing implementation.
- Enhanced clinician education and accessible genetics support are vital for expanding genetic testing in rural areas.
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