New compounds from the leaves of Coriaria nepalensis

Four undescribed compounds, including one new sesquiterpene lactone (1, coriarilactone A), two new phenylpropanoid glycosides (2 and 3, corianosides A and B), and one new coumarin (4, coriacoumarin A), together with five known sesquiterpenes, were isolated from the leaves of the toxic medicinal plant Coriaria nepalensis. The structures of 1-4 were elucidated through a combination of extensive NMR spectroscopic analysis, HRESIMS, and X-ray crystallography. Notably, compounds 2-3 possess a rare heptose moiety, which were isolated from the Coriariaceae family for the first time. Compound 1 exhibited potential neuroprotective activity. All compounds showed no convulsant neurotoxicity and no remarkable inhibitory activity toward four human cancer cell lines.