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A Wide-Band Coplanar Waveguide Delivery System for Sub-Nanosecond Pulsed Electric Fields Exposure.

Hafsa Tjiou¹, Lionel Michard¹, Abdelkhalek Nasri¹

¹University of Limoges, CNRS, XLIM, UMR, Limoges, France.

|July 6, 2026

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We developed a microfluidic device using a coplanar waveguide (CPW) for precise cellular manipulation with sub-nanosecond pulsed electric fields (sub-nsPEFs). This device efficiently delivers high-intensity electric fields for advanced biomedical research.

Area of Science:

Electrical Engineering
Biomedical Engineering
Physics

Background:

Sub-nanosecond pulsed electric fields (sub-nsPEFs) are emerging as a powerful technique for cellular and intracellular manipulation.
Existing methods for delivering sub-nsPEFs often face challenges in achieving high intensity and precise control.
Microfluidic devices offer a platform for controlled biological sample handling and precise field application.

Purpose of the Study:

To design and characterize a novel microfluidic device utilizing a coplanar waveguide (CPW) for high-intensity sub-nsPEF delivery.
To evaluate the device's performance for biomedical investigations requiring precise electro-manipulation.
To confirm the capability of delivering ultra-short duration, high-intensity electric pulses.

Main Methods:

Keywords:

coplanar waveguide (CPW)high intensity microfluidic systems sub-nanosecond pulsed electric fields

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Development of a microfluidic device featuring a coplanar waveguide (CPW) with a miniaturized gap width (345 µm).
Utilized numerical simulations and experimental measurements to assess device performance.
Characterized the device under high-voltage sub-nanosecond pulse exposure.

Main Results:

The CPW device demonstrated a return loss below -10 dB across a broad frequency range up to 3.7 GHz.
Confirmed homogeneous electric field distribution within the CPW channels, ideal for sample exposure.
Successfully delivered electric pulses of approximately 18 MV/m intensity and 500 ps duration.

Conclusions:

The proposed CPW-based microfluidic device is highly suitable for delivering high-intensity sub-nsPEFs.
The device enables precise and homogeneous electric field application for cellular and intracellular electro-manipulation.
This technology holds significant potential for advancing biomedical research and applications utilizing pulsed electric fields.