Related Experiment Video

Updated: Jul 8, 2026

Tissue-specific miRNA Expression Profiling in Mouse Heart Sections Using In Situ Hybridization
08:22

Tissue-specific miRNA Expression Profiling in Mouse Heart Sections Using In Situ Hybridization

Published on: September 15, 2018

Circulating MicroRNAs and Clinical Parameters in Hypertrophic Cardiomyopathy: A Systematic Review and Correlation

Antonio da Silva Menezes Junior1,2, Henrique Lima de Oliveira1, Khissya Beatryz Alves de Lima1

  • 1Department of Medicine, Federal University of Goiás, Goiânia, GO 74605-050, Brazil.

Frontiers in Bioscience (Scholar Edition)
|July 7, 2026
PubMed

Insights

Circulating microRNAs (miRNAs) show significant correlations with cardiac structural and functional changes in hypertrophic cardiomyopathy (HCM). These findings suggest miRNAs may serve as valuable noninvasive biomarkers for HCM, though further research is needed.

Area of Science:

  • Cardiology
  • Genetics
  • Biomarker Discovery

Background:

  • Hypertrophic cardiomyopathy (HCM) is a genetically diverse heart condition.
  • Left ventricular hypertrophy, myocardial fibrosis, and varied clinical symptoms characterize HCM.
  • Circulating microRNAs (miRNAs) are potential biomarkers for cardiac remodeling, but their link to specific HCM characteristics is not well understood.

Purpose of the Study:

  • To systematically review and quantify the association between circulating miRNAs and structural/functional cardiac parameters in HCM.
  • To explore the potential of miRNAs as noninvasive biomarkers for HCM.

Main Methods:

  • A systematic review and meta-analysis of 11 observational studies involving 633 patients.
  • Searched PubMed, Embase, Scopus, and Web of Science databases.
  • Analyzed correlations between miRNA expression and echocardiography, MRI, and histological data using random-effects models.

Main Results:

  • Moderate-to-strong positive correlations found between specific miRNAs (miR-21, miR-29a, miR-199a-5p, miR-27a) and myocardial fibrosis, wall thickness, and left ventricular mass (r = 0.53).
  • Sensitivity and meta-regression analyses confirmed result robustness.
  • Moderate concerns identified in risk-of-bias assessment, mainly regarding patient selection and blinding.

Conclusions:

  • Circulating miRNAs are significantly associated with cardiac structural and functional alterations in HCM.
  • These miRNAs show promise as noninvasive biomarkers for HCM.
  • High-quality studies are required to confirm their clinical utility.
Abstract

Keywords:
biomarkerscorrelationdiagnostichypertrophic cardiomyopathymicroRNA

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