Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Prescription, Nonprescription and Orphan Drugs01:02

Prescription, Nonprescription and Orphan Drugs

Prescription drugs require a prescription from a medical practitioner and can only be obtained from a pharmacy. They have many applications, including treating pain, anxiety, and hypertension.
The misuse and addiction to prescription drugs is a growing problem that can affect people of all age groups, specifically teenagers. This can happen when prescription medications are used in ways not intended by the prescriber, such as taking someone else's prescription or using medication for...
Opioid Analgesics: Synthetic and Semisynthetic Opioids01:15

Opioid Analgesics: Synthetic and Semisynthetic Opioids

Synthetic and semisynthetic opioids are pivotal in pain management and tackling opioid addiction. Semisynthetic opioids, including morphinans (morphine derivatives), oxycodone, oxymorphone, hydrocodone, and hydromorphone, have improved pharmacokinetic profiles compared to morphine. Additionally, heroin and 6-MAM (6-Monoacetylmorphine) show better CNS penetration than morphine due to heightened lipid solubility. Hydromorphone, a potent opioid, undergoes hepatic metabolism to form the active...
Stimulants01:29

Stimulants

Stimulants are substances that enhance neural activity and elevate dopamine levels in the brain, leading to their highly addictive nature. These drugs include cocaine, amphetamines, MDMA, caffeine, and nicotine, each with distinct mechanisms of action and varied health implications.
Cocaine can be administered via snorting, injection, or smoking. It primarily functions by blocking the reuptake of dopamine, resulting in a euphoric high characterized by an intense sensation of happiness and...
Pharmaceutical Poisoning: Potential Scenarios01:26

Pharmaceutical Poisoning: Potential Scenarios

Pharmaceutical poisoning can occur through various channels, impacting an estimated 2 million hospitalized patients in the U.S. annually with serious adverse drug responses. These scenarios encompass both therapeutic uses, such as drug toxicity, where even standard dosages can lead to severe central nervous system depression, and non-therapeutic exposures, including accidental ingestion by children, and environmental and occupational exposures.Unintentional poisonings often involve exploratory...
Drug Abuse and Addiction: Pharmacological Phenomena01:15

Drug Abuse and Addiction: Pharmacological Phenomena

Drug dependence, abuse, and addiction are complex phenomena that can precipitate various abnormal states. Physical dependence refers to a state of pharmacological adaptation to a drug. This adaptation often results in tolerance—a reduced response to the drug after repeated administrations. When the drug use is abruptly stopped, withdrawal symptoms occur due to the body's need to readjust from the pharmacologically induced imbalance. However, tolerance and withdrawal symptoms do not necessarily...
Opioid Analgesics: Morphine and Other Natural Cogeners01:20

Opioid Analgesics: Morphine and Other Natural Cogeners

Opioids are a class of drugs that mimic endogenous opioid peptides and act on opioid receptors, and help in pain relief. These compounds are classified as natural, synthetic, or semi-synthetic. Natural opioids, like morphine, codeine, and thebaine, are derived from the opium poppy plant (Papaver somniferum or Papaver album) and are termed opiates. Synthetic opioids are artificial, while semi-synthetic opioids combine natural and synthetic compounds. Morphine, a prototypical opioid, possesses a...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Sleep Duration Among US Adolescents, 1991-2023.

Pediatrics·2026
Same author

Cannabis use disorder risk among midlife adults reporting medical and nonmedical cannabis use, 2019-2024.

Drug and alcohol dependence·2026
Same author

Nicotine Pouch Use Among U.S. Adults in 2023 and 2024.

American journal of preventive medicine·2026
Same author

The Impact of Layering Tobacco 21 Laws and Smoke-Free Laws on U.S. Adolescent Smoking Behaviors.

American journal of preventive medicine·2026
Same author

Neighborhood Disadvantage and Adolescent Substance Use: Differences by Urbanicity and Substance Type.

Journal of studies on alcohol and drugs·2026
Same author

Trends in Weight Status and E-Cigarette Use Among U.S. Youth From 2017 to 2023.

American journal of preventive medicine·2026
Same journal

Suicidal Ideation and the Wider Value of Structured Care in Major Depression-Before the Near Miss.

JAMA network open·2026
Same journal

Interval Salpingectomy-Can We Have It All?

JAMA network open·2026
Same journal

What Patients Want From AI-Drafted Portal Messages-Empathy in the In-Basket.

JAMA network open·2026
Same journal

Hospital-Based Psychosocial Case Management and Suicide Prevention in South Korea: A Randomized Clinical Trial.

JAMA network open·2026
Same journal

Incidence of Recurrent Invasive Pneumococcal Disease in Canada.

JAMA network open·2026
Same journal

Opioid Use and Pain Resolution for Acute Pain Among Opioid-Naive Patients.

JAMA network open·2026
See all related articles

Related Experiment Video

Updated: Jul 8, 2026

Fentanyl Analog Screening using LC-TIMS-TOF MS/MS
10:13

Fentanyl Analog Screening using LC-TIMS-TOF MS/MS

Published on: November 8, 2024

Perceived Risk of Fentanyl Use Among US Adolescents.

Richard Miech1, Megan E Patrick1, Justin Jager1

  • 1Institute for Social Research, University of Michigan, Ann Arbor.

JAMA Network Open
|July 7, 2026
PubMed
Summary
This summary is machine-generated.

Many adolescents, especially younger ones, underestimate fentanyl's dangers. Increased awareness campaigns are crucial to inform youth about the severe risks of fentanyl use and prevent overdose deaths.

More Related Videos

Administration of Δ9-Tetrahydrocannabinol (THC) in Adolescent and Adult Mice
07:51

Administration of Δ9-Tetrahydrocannabinol (THC) in Adolescent and Adult Mice

Published on: August 1, 2025

Related Experiment Videos

Last Updated: Jul 8, 2026

Fentanyl Analog Screening using LC-TIMS-TOF MS/MS
10:13

Fentanyl Analog Screening using LC-TIMS-TOF MS/MS

Published on: November 8, 2024

Administration of Δ9-Tetrahydrocannabinol (THC) in Adolescent and Adult Mice
07:51

Administration of Δ9-Tetrahydrocannabinol (THC) in Adolescent and Adult Mice

Published on: August 1, 2025

Area of Science:

  • Adolescent Health
  • Public Health
  • Substance Use Research

Background:

  • Adolescent overdose mortality from fentanyl has risen, highlighting the urgent need to understand youth perceptions of fentanyl risks.
  • Youth awareness of fentanyl's dangers is critical in mitigating the escalating crisis of adolescent opioid overdoses.

Purpose of the Study:

  • To determine US national estimates of perceived risk associated with experimental, occasional, and regular fentanyl use among adolescents.
  • To identify demographic and grade-level variations in adolescent risk perception of fentanyl.

Main Methods:

  • A cross-sectional survey was administered to a nationally representative sample of 8th, 10th, and 12th-grade students in 2025.
  • Data from the Monitoring the Future study were analyzed using multiple imputation and Poisson regression models to assess perceived risks of fentanyl use.

Main Results:

  • Perceived risk of fentanyl use increased with grade level, with 12th graders showing the highest risk awareness.
  • Significant disparities were observed, with non-Hispanic White students generally perceiving higher risks, while Hispanic and non-Hispanic Black students reported lower risks in certain grades.
  • Adolescents in rural areas exhibited higher perceived risk levels in 8th and 10th grades.

Conclusions:

  • A notable proportion of adolescents, particularly younger students, lack awareness regarding the severe dangers of fentanyl.
  • Effective communication strategies involving clinicians, parents, schools, and public health programs are essential to educate adolescents about the life-threatening risks of fentanyl misuse.