Related Experiment Video
Updated: Jul 9, 2026
08:59
T and B Cell Receptor Immune Repertoire Analysis using Next-generation Sequencing
Published on: January 12, 2021
Identification of a Novel HLA-B Allele, HLA-B*35:640, Discovered by Next-Generation Sequencing
Nedal Taha1, Dawn Wagenknecht1, Jackie Winstead1
1LifeLink Transplantation Immunology Laboratory, Tampa, Florida, USA.
HLA
|July 8, 2026
Abstract:
The novel HLA-B*35:640 allele differs from B*35:01:01:01 by a non-synonymous change in Exon 7.
Related Concept Videos
03:00Next-generation Sequencing
The first human genome sequencing project cost $2.7 billion and was declared complete in 2003, after 15 years of international cooperation and collaboration between several research teams and funding agencies. Today, with the advent of next-generation sequencing technologies, the cost and time of sequencing a human genome have dropped over 100 fold.
Next-Generation Sequencing Methods
Although all next-generation methods use different technologies, they all share a set of standard features.
Next-Generation Sequencing Methods
Although all next-generation methods use different technologies, they all share a set of standard features.
01:11Genome-wide Association Studies-GWAS
Genome-wide association studies or GWAS are used to identify whether common SNPs are associated with certain diseases. Suppose specific SNPs are more frequently observed in individuals with a particular disease than those without the disease. In that case, those SNPs are said to be associated with the disease. Chi-square analysis is performed to check the probability of the allele likely to be associated with the disease.
GWAS does not require the identification of the target gene involved in...
GWAS does not require the identification of the target gene involved in...