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Benefits of Cardiac Resynchronization Therapy in an Asynchronous Heart Failure Model Induced by Left Bundle Branch Ablation and Rapid Pacing
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Long-Term Heart Failure Stabilization and Autonomic Trends After Bilateral Cardiac Sympathetic Denervation

Yuko Miki1, Shingo Yoshimura1, Takehito Sasaki1

  • 1Division of Cardiology, Gunma Prefectural Cardiovascular Center, Maebashi, Gunma, Japan.

JACC. Case Reports
|July 9, 2026
PubMed

Insights

Bilateral cardiac sympathetic denervation (CSD) offers a temporary benefit for heart failure (HF) and ventricular tachycardia (VT) by improving left ventricular (LV) remodeling. However, its effects may wane over time, as indicated by device diagnostics.

Area of Science:

  • Cardiology
  • Autonomic Nervous System Research
  • Medical Device Technology

Background:

  • Bilateral cardiac sympathetic denervation (CSD) is a treatment for refractory ventricular tachycardia (VT).
  • The impact of CSD on heart failure (HF) progression and left ventricular (LV) remodeling remains incompletely understood.
  • Investigating CSD's long-term effects is crucial for managing complex cardiac conditions.
Abstract

Keywords:
chronic heart failurereduced ejection fractionventricular tachycardia

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