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Identification of the Novel HLA-G*01:71 Allele Using PolyseqOne Nanopore Sequencing Technology
Xiayan Li1, Yuan Yao2, Chengyan Fang3
1Department of Blood Transfusion, Affiliated Hospital of Yunnan University, Kunming, China.
HLA
|July 9, 2026
Summary
A novel Human Leukocyte Antigen-G (HLA-G) allele, HLA-G*01:71, has been identified. This new allele is distinguished from a common variant by a single genetic alteration in exon 3.
Area of Science:
- Immunogenetics
- Molecular biology
- Human leukocyte antigen research
Background:
- The Human Leukocyte Antigen-G (HLA-G) molecule plays a crucial role in immune tolerance, particularly during pregnancy and transplantation.
- Polymorphisms in HLA-G genes contribute to diverse immune responses and disease susceptibility.
Purpose of the Study:
- To report the discovery and characterization of a new HLA-G allele, designated HLA-G*01:71.
- To describe the specific genetic variation differentiating this new allele from known alleles.
Main Methods:
- Sequence analysis of the HLA-G gene.
- Comparison of nucleotide sequences to identify variations.
Main Results:
- A novel HLA-G allele, HLA-G*01:71, was identified.
- This allele differs from the common HLA-G*01:01:02 allele by a single nonsynonymous nucleotide substitution.
- The substitution occurs at codon 165 within exon 3 of the HLA-G gene.
Conclusions:
- The identification of HLA-G*01:71 expands the known repertoire of HLA-G polymorphism.
- This finding contributes to a deeper understanding of HLA-G diversity and its potential implications in immunogenetics.
