Related Experiment Video
Updated: Jul 12, 2026
07:46
Experimental Endocarditis Model of Methicillin Resistant Staphylococcus aureus (MRSA) in Rat
Published on: June 4, 2012
Native valve endocarditis due to Staphylococcus kloosii: a brief report
Anne-Marie Dolan1, Sinead McDermott2, Grainne Brennan3
1Department of Clinical Microbiology, St. James Hospital, Dublin 8, Dublin, Ireland. annemariedolanmicro@gmail.com.
Summary
This case report details Staphylococcus kloosii causing native valve endocarditis (NVE). Repeatedly misidentified as contaminants, this rare coagulase-negative staphylococci (CoNS) species highlights the need for thorough microbiological evaluation.
Area of Science:
- Infectious Diseases
- Microbiology
- Cardiology
Background:
- Native valve endocarditis (NVE) is a serious infection, typically caused by Staphylococcus aureus or Streptococcus species.
- Coagulase-negative staphylococci (CoNS) are often considered contaminants, but can cause invasive infections, especially in patients with comorbidities.
- Delayed diagnosis of NVE can lead to severe complications, including heart failure and valve damage.
Purpose of the Study:
- To report the first case of NVE caused by Staphylococcus kloosii.
- To emphasize the clinical significance of CoNS in blood cultures.
- To highlight the importance of accurate identification and evaluation of CoNS isolates.
Main Methods:
- Case report of a 70-year-old male with NVE.
- Review of clinical records, imaging, and microbiological data from three hospitals.
- Retrospective analysis of blood cultures.
- Identification of S. kloosii using MALDI-TOF and 16S rRNA sequencing.
Main Results:
- S. kloosii was identified as the causative agent of NVE in a patient with multiple comorbidities.
- S. kloosii isolates from prior admissions were initially misinterpreted as contaminants.
- The patient underwent mitral valve replacement and received targeted antimicrobial therapy.
- A favorable outcome was achieved despite a drug-related adverse event.
Conclusions:
- Rare CoNS species, such as S. kloosii, can cause invasive infections like NVE.
- Repeated isolation of CoNS across multiple healthcare encounters warrants thorough clinical investigation.
- Accurate microbiological identification and clinical correlation are crucial for timely diagnosis and improved patient outcomes in NVE.
Related Concept Videos
01:25Endocarditis I: Introduction
Introduction:Endocarditis is the infection of the endocardium, the inner lining of the heart and its valves. When the heart muscle is involved, the condition is termed myocarditis, while an infection of the outer lining is called pericarditis. Infective endocarditis (IE) primarily affects the endocardium, where pathogens adhere to the valves or lining, forming vegetation that can lead to severe complications. Infective endocarditis occurs when microorganisms, usually bacteria from other body...
01:25Endocarditis II: Clinical Features of Infective Endocarditis
Endocarditis can present various clinical features depending on the causative organism and the patient's underlying health conditions. Initially, the clinical features of infective endocarditis develop gradually, presenting with nonspecific symptoms that can be easily mistaken for other illnesses.General SymptomsEarly symptoms of infective endocarditis are fever, chills, weakness, malaise, fatigue, and weight loss. These symptoms reflect the systemic nature of the infection and the body's...
01:29Endocarditis IV: Nursing Management
Infective endocarditis (IE) is a chronic infection of the heart's endocardium, primarily affecting the heart valves. A detailed nursing assessment for a patient with IE involves collecting subjective and objective data to ensure an accurate diagnosis and timely intervention.Subjective DataThe nurse gathers information about the patient's symptoms and complaints during the subjective assessment. Patients with infective endocarditis often report non-specific symptoms that can mimic other...
01:18Endocarditis III: Medical Management
Infective endocarditis management involves a multifaceted approach encompassing infection prevention, lifestyle modifications, pharmacological therapy, and surgical management.Infection Prevention:Hand Hygiene: Thorough handwashing is crucial to prevent the spread of infection. Hand hygiene should be performed regularly, especially before and after using the restroom.Oral Hygiene: Good oral hygiene is essential. It includes brushing teeth immediately after waking up and before bed, flossing...
01:22Mitral Stenosis I: Introduction
Mitral Valve Stenosis (MVS) is a heart condition where the mitral valve narrows, impeding blood circulation from the left atrium to the left ventricle. The etiology and pathophysiology of this condition are multifaceted, leading to a cascade of cardiovascular complications.Causes of Mitral Valve StenosisRheumatic Heart Disease: It is the main cause of mitral valve stenosis, particularly in developing nations. This condition arises from rheumatic fever, an inflammatory illness resulting from...
01:26Mitral Stenosis III: Medical Management
Mitral stenosis, a condition marked by the narrowing of the mitral valve, necessitates an integrated approach for effective management. This approach includes preventative measures, medical therapy, and surgical interventions to reduce symptoms and prevent complications.PreventionPrevention of mitral stenosis primarily focuses on reducing the incidence of bacterial infections, particularly streptococcal infections, which can lead to rheumatic fever and subsequent valvular damage. Timely...