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Updated: Jul 12, 2026

Preparation and Characterization of Lipophilic Doxorubicin Pro-drug Micelles

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Published on: August 2, 2016

Development and Characterization of Ultrasound-Activated Polymeric Microdroplets for Targeted Chemotherapy.

Joshua Antonio Whiting, Audri Yasmin Al Hasan Dara, James Francis Kwan

Biorxiv : the Preprint Server for Biology

|July 10, 2026

Summary

Researchers developed ultrasound-sensitive microdroplets for targeted chemotherapy. This novel drug delivery system precisely releases potent antineoplastics like afatinib and doxorubicin at the tumor site, minimizing systemic toxicity and enabling dose-dependent treatment.

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Preparation and Characterization of Individual and Multi-drug Loaded Physically Entrapped Polymeric Micelles

Preparation and Characterization of Individual and Multi-drug Loaded Physically Entrapped Polymeric Micelles

Published on: August 28, 2015

Area of Science:

Biomaterials Science
Drug Delivery Systems
Oncology

Background:

Potent antineoplastic drugs, such as afatinib and doxorubicin, can cause systemic toxicity.
Targeted drug delivery aims to improve therapeutic efficacy and reduce side effects.

Purpose of the Study:

To develop an ultrasound-triggered drug delivery vehicle for targeted chemotherapy.
To encapsulate and release hydrophobic antineoplastic agents, including afatinib and doxorubicin.

Main Methods:

Fabrication of ultrasound-sensitive microdroplets using methoxy poly(ethylene glycol)-poly(D, L-lactide) (mPEG-PDLLA) and perfluorooctyl bromide (PFOB).
Encapsulation of afatinib and doxorubicin via co-evaporation.
Assessment of encapsulation efficiencies and ultrasound-dependent drug release kinetics.

Main Results:

High encapsulation efficiencies achieved: 39.6% for afatinib and 46.6% for doxorubicin.
Ultrasound-triggered release of both drugs in a pressure-dependent manner (P50 values of 0.61 MPa for doxorubicin and 0.72 MPa for afatinib).
Demonstrated dose-dependent drug release controlled by ultrasound duration.

Conclusions:

The developed microdroplets offer an effective platform for targeted chemotherapy delivery.
This approach mitigates off-target effects by enabling focal drug release at the ultrasound focus.
The system provides a foundation for future advancements in targeted cancer therapies.