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Biomarkers of Sarcopenia: Current Status and Future Perspectives
Bijin Luo1, Wenhan Li1, Yi Zhang1
1Department of Geriatrics Union Hospital, Tongji Medical College, Huazhong University of Science and Technology Wuhan China.
Sarcopenia, an age-related muscle disorder, lacks standardized diagnosis. Emerging biomarkers in biochemical, imaging, and physical performance categories show promise for early detection and personalized management of this condition.
Area of Science:
- Gerontology
- Muscle physiology
- Biomarker research
Background:
- Sarcopenia is a progressive age-related skeletal muscle disorder impacting quality of life in older adults.
- Current diagnostic criteria for sarcopenia exhibit heterogeneity, challenging accurate and early detection.
- Biomarkers offer potential to improve sarcopenia diagnosis, monitoring, and treatment.
Purpose of the Study:
- To review established and emerging biomarkers for sarcopenia.
- To analyze the biological relevance, clinical utility, and limitations of these biomarkers.
- To discuss future research directions for integrated biomarker strategies.
Main Methods:
- Narrative review of scientific literature.
- Classification of biomarkers into biochemical, imaging-based, and physical performance-related categories.
- Synthesis of findings on biomarker relevance, applicability, and limitations.
Main Results:
- Biomarkers are crucial for enhancing diagnostic accuracy and monitoring sarcopenia progression.
- Identified biomarkers span biochemical, imaging, and physical performance domains.
- Heterogeneity in current diagnostic tools necessitates novel biomarker approaches.
Conclusions:
- Biomarkers are vital for advancing the early detection, risk stratification, and personalized management of sarcopenia.
- Multimodal biomarker strategies are essential for comprehensive sarcopenia care.
- Further research is needed to validate and integrate novel biomarkers into clinical practice.
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