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Updated: Jul 12, 2026

Synthesis and Characterization of 1,2-Dithiolane Modified Self-Assembling Peptides
Published on: August 20, 2018
A supramolecular assembly of a disulfide-linked adamantane-curcumin conjugate and amphiphilic cyclodextrin with
Roberto Zagami1,2, Chiara M A Gangemi1, Giuseppe Nocito2
1Dept. of Chemical, Biological, Pharmaceutical and Environmental Sciences (ChiBioFarAm), University of Messina, Viale F. Stagno d'Alcontres, 31, 98166 Messina, Italy. chigangemi@unime.it.
Abstract:
The synthesis of a novel unsymmetrical disulfide-linked adamantane-curcumin conjugate and its supramolecular assembly with amphiphilic cyclodextrin in aqueous dispersion is herein reported. Within the nanoassemblies, a curcumin derivative was dissolved up to 0.14 mg mL-1 in ultrapure water. The derivative was also highly dispersible in other biologically relevant media (e.g., NaCl 0.9 wt% and PBS pH 7.4), and exhibited redox-responsiveness in the presence of glutathione as a reducing agent.
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