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Updated: Jul 12, 2026
Induction of Atherosclerotic Plaques Through Activation of Mineralocorticoid Receptors in Apolipoprotein E-deficient Mice
Published on: September 26, 2018
A comparative study on the pharmacological effects of Achyranthes root against atherosclerosis in ApoE-/- mice based
Xiaoming Zou1, Jie Su2, Bingbing Gao3
1The First Affiliated Hospital of Zhejiang Chinese Medical University (Zhejiang Provincial Hospital of Chinese Medicine), Hangzhou, Zhejiang, 310006, P.R. China.
Background:
In traditional Chinese medicine, herbal processing is used to modify the effects of herbs. Achyranthes bidentata BL (Niu Xi) is commonly used to treat atherosclerosis and cardiovascular diseases, in both raw (RC) and salted (SRC) forms. Salting is known to enhance its effects, particularly on kidney function, but the differences in anti-atherosclerosis efficacy between RC and SRC have not been studied.
Results:
A total of 491 and 501 chemical components were identified in RC and SRC, respectively, with 337 shared components. RC at a high dose (2.4 g/kg/d) was more effective against AS than the same dose of SRC over 12 weeks. Both RC and SRC increased SDF-1, SCF-1, and CXCR4 levels in the aorta of model mice compared to controls, suggesting these agents may protect the vascular endothelium through a related signaling axis. A gray relational analysis of 19 common components using UPLC-MS peak areas showed correlations (gray relational value > 0.6) with serum total cholesterol and bone marrow SDF-1 levels.
Conclusions:
Both RC and SRC have anti-AS effects, but salt-processing does not improve this activity.
