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Pembrolizumab-Associated Serositis With Recurrent Pleural Effusions Successfully Treated With Anakinra
Emma McNally1,2, Sean Garvey1, Malcolm Herron1
1Respiratory Department St James's Hospital Dublin Ireland.
Clinical Case Reports
|July 13, 2026
Abstract
None:
Immune checkpoint inhibitor-associated serositis is rare and may present with recurrent effusions. Some cases are steroid dependent, contributing to significant toxicity for patients. Guidance on steroid-sparing therapy is limited. Our case describes IL-1 blockade with anakinra which was well tolerated and effective, supporting its use as a steroid-sparing option.
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