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Updated: Jul 15, 2026
08:19
Hollow Microneedle-based Sensor for Multiplexed Transdermal Electrochemical Sensing
Published on: June 1, 2012
Polymeric microneedles for closed-loop drug delivery: from biosensing to therapy.
V Mythily1, B S Sreeja1, S Fouziya Sulthana2
1Department of Biomedical Engineering, College of Engineering Guindy, Anna University Chennai 600025 India.
RSC Advances
|July 14, 2026
Summary
Polymeric microneedles (PMNs) offer advanced transdermal drug delivery and biosensing. These smart systems enable autonomous monitoring and feedback control for chronic disease management, paving the way for precision medicine.
Area of Science:
- Biomaterials Science
- Nanotechnology
- Drug Delivery Systems
Background:
- Polymeric microneedles (PMNs) are innovative platforms for drug delivery and biosensing.
- They integrate polymer chemistry, microfabrication, and bioelectronics for enhanced functionality.
- Recent progress enables closed-loop systems for autonomous sensing and therapeutic feedback.
Purpose of the Study:
- To provide a comprehensive review of polymeric microneedle technologies.
- To analyze material properties, fabrication methods, and performance metrics.
- To discuss applications in biosensing, drug delivery, and chronic disease management.
Main Methods:
- Review of current literature on polymeric microneedle research.
- Analysis of polymer classification, material properties, and fabrication techniques.
- Evaluation of mechanical, biological, and sensing performance.
Main Results:
- PMNs facilitate controlled delivery of diverse therapeutics and real-time biomarker monitoring.
- Stimuli-responsive polymers and hydrogel-forming microneedles show promise for precision medicine.
- Closed-loop systems demonstrate potential for autonomous chronic disease management.
Conclusions:
- Polymeric microneedles represent a versatile platform for advanced transdermal applications.
- Future directions include smart, wearable, and self-regulated microneedle systems.
- Addressing manufacturing scalability and regulatory hurdles is crucial for clinical translation.
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