Related Experiment Video
Updated: Jul 15, 2026
03:40
Acupoint Catgut Embedding Therapy in Traditional Chinese Medicine for Managing Allergic Rhinitis
Published on: December 20, 2024
Routine lipid profiles in allergic disease: a mini review.
1Division of Allergy and Clinical Immunology, Department of Internal Medicine, Chungbuk National University Hospital, Cheongju, Republic of Korea.
Frontiers in Allergy
|July 14, 2026
Summary
Routine lipid profiles, including HDL, LDL, and triglycerides, offer new insights into allergic diseases like asthma and atopic dermatitis. These accessible markers may link metabolism to immune regulation, aiding clinical stratification.
Area of Science:
- Immunology
- Metabolic Science
- Allergy Research
Background:
- Allergic diseases traditionally focus on barrier dysfunction and immune activation.
- Serum lipid profiles (HDL, LDL, TG) are typically viewed as cardiometabolic risk markers.
- Emerging evidence links routine lipids to systemic inflammation in allergic conditions.
Purpose of the Study:
- To review current evidence on routine lipid profiles in asthma, atopic dermatitis, and allergic rhinitis.
- To explore clinical associations, disease-specific differences, and immune mechanisms.
- To assess the potential of lipid profiles as markers connecting metabolism and allergic immune regulation.
Main Methods:
- Systematic review of existing clinical and mechanistic studies.
- Analysis of associations between lipid profiles and allergic disease burden, complexity, and outcomes.
- Investigation of potential roles in immune cell regulation (e.g., eosinophils, ILC2s).
Main Results:
- Asthma shows the strongest clinical relevance, with lipid abnormalities linked to disease burden and outcomes.
- Atopic dermatitis: circulating lipids are less central than epidermal lipids but may reflect metabolic/CV risks.
- Allergic rhinitis: associations are inconsistent, but HDL's role in immune cell regulation is mechanistically relevant.
Conclusions:
- Routine lipid profiles can serve as accessible markers linking systemic metabolism to allergic immune regulation.
- These measures may refine clinical stratification and generate hypotheses for lipid-immune crosstalk.
- Further research integrating lipid panels with functional assays and tissue immunology is needed for clinical application.
Related Concept Videos
01:26Atherosclerosis III: Management
Management of atherosclerosis involves an integrated strategy encompassing pharmacological treatment, surgical interventions, lifestyle changes, and nutrition therapy to address the multifactorial nature of the disease.Pharmacological TherapyA cornerstone of atherosclerosis management is the use of pharmacological agents. Statins, such as atorvastatin, are pivotal in inhibiting HMG-CoA reductase, an enzyme that catalyzes an initial step in cholesterol synthesis in the liver. This reduction in...
01:30Allergic Reactions: Anaphylaxis
Anaphylaxis is a severe, life-threatening hypersensitivity reaction mediated by Immunoglobulin E (IgE) antibodies. When IgE binds to allergens, it triggers the release of mediators– histamine, leukotrienes, and prostaglandins from mast cells and basophils. These mediators cause vasodilation, edema, and inflammation, leading to various symptoms.The primary allergens causing anaphylaxis include food items (e.g., peanuts, shellfish), drugs (e.g., penicillin, asparaginase, corticotropin, heparin),...
01:28Asthma I: Introduction
Asthma is a chronic inflammatory disorder of the airways characterized by variable airflow obstruction and heightened bronchial responsiveness to a wide range of triggers. The underlying inflammation leads to airway swelling, mucus hypersecretion, and smooth muscle constriction, all of which narrow the airway lumen and impede airflow. Clinically, asthma presents with recurrent episodes of wheezing, shortness of breath, chest tightness, and coughing, symptoms that typically vary in intensity and...
01:19Antiasthma Drugs: Leukotriene Modifiers
Leukotriene modifiers, or cysteinyl leukotriene receptor antagonists, are medications used to manage chronic asthma. These agents target specific inflammatory mediators produced during arachidonic acid metabolism, an essential process in generating inflammation in the body.
Leukotriene modifiers work through two distinct mechanisms:
Leukotriene modifiers work through two distinct mechanisms:
01:17Drugs Used in Lower Respiratory Disorders: Overview
Lower respiratory tract disorders present challenges that often require skilled and nuanced approaches for effective management. Common ailments, such as asthma and chronic obstructive pulmonary disease (COPD), have prompted the development of intricate treatment strategies involving bronchodilators and anti-inflammatory drugs, each tailored to ease breathing and revitalize the lungs.
Bronchodilators, the first step of respiration enhancement, come in various forms, each with its own mechanism...
Bronchodilators, the first step of respiration enhancement, come in various forms, each with its own mechanism...
01:30Drug Toxicity: Allergic Reactions
Drug-related allergies are immune-mediated responses triggered by the administration of pharmacological agents. These hypersensitivity reactions are classified based on the immune mechanisms involved. The four primary types—Type I, II, III, and IV—are mediated by different immunological pathways and exhibit distinct clinical manifestations.Type I Hypersensitivity/ IgE-Mediated Reactions: Immunoglobulin E (IgE) immediately mediates Type I hypersensitivity reactions. Upon initial exposure to a...