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The Novel HLA-DQA1*01:204 Allele Identified in Asian Female Donor by Next-Generation Sequencing

Jasmine Ge1, Vasudha Eravelli1, Sharon Austria1

  • 1Histocompatibility and Immunology Laboratory, The Mount Sinai Hospital, New York, New York, USA.

HLA
|July 14, 2026
PubMed

Abstract:

HLA-DQA1*01:204 differs from HLA-DQA1*01:02:01:01 by one nucleotide substitution in codon 216 in exon 4.

Keywords:
HLA‐DQA1*01:204next‐generation sequencing (NGS)transplantation

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Genome-wide association studies or GWAS are used to identify whether common SNPs are associated with certain diseases. Suppose specific SNPs are more frequently observed in individuals with a particular disease than those without the disease. In that case, those SNPs are said to be associated with the disease. Chi-square analysis is performed to check the probability of the allele likely to be associated with the disease.
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