Advances in quercetin-based therapeutics for breast cancer: natural, synthetic, and nanotechnology-driven approaches

Area of Science:

• Oncology
• Pharmacology
• Natural Products Chemistry

Background:

• Breast cancer is a leading cause of death in women, with conventional chemotherapy facing limitations like drug resistance and toxicity.
• Naturally derived compounds, particularly flavonoids like quercetin, offer potential as safer alternatives by modulating cancer pathways.
• Challenges with quercetin include poor bioavailability and rapid metabolism, necessitating formulation improvements.

Purpose of the Study:

• To review the role of quercetin and its metabolites in breast cancer prevention and treatment.
• To examine the molecular targets and pharmacodynamic effects of quercetin in breast cancer.
• To discuss strategies for enhancing quercetin's therapeutic potential, including derivatives and nanomaterials.

Main Methods:

• Literature review of studies on quercetin, its metabolites, derivatives, and nanomaterials in breast cancer.
• Analysis of molecular targets and pharmacodynamic effects.
• Evaluation of formulation strategies for improved bioavailability and targeted delivery.

Main Results:

• Quercetin demonstrates potential in modulating key breast cancer pathways with minimal side effects.
• Quercetin derivatives and nanomaterials show promise in overcoming bioavailability and delivery challenges.
• Current research indicates a need for optimized, targeted quercetin formulations for clinical application.

Conclusions:

• Quercetin and its advanced formulations represent a promising avenue for breast cancer therapy.
• Further development is needed to address translational hurdles and optimize quercetin-based treatments.
• Targeted delivery and improved stability of quercetin are crucial for clinical viability in breast cancer treatment.