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Related Concept Videos

Site-Targeted Drug Delivery Systems: Polymeric Carriers01:24

Site-Targeted Drug Delivery Systems: Polymeric Carriers

Polymeric carriers enhance targeted drug delivery by increasing efficacy while minimizing off-target effects. These carriers comprise a biodegradable polymeric backbone integrated with functional elements that enable targeting, improve physicochemical properties, and regulate drug release.Targeting MechanismsThe targeting ability of polymeric carriers is mediated by a homing device, which is a molecular recognition component designed to selectively bind to specific tissues or cells. Monoclonal...
Drug Delivery Systems: Different Types01:27

Drug Delivery Systems: Different Types

Conventional oral drug products, termed immediate-release (IR) formulations, are engineered to promptly release their active pharmaceutical ingredient (API) upon ingestion, typically in tablets or capsules. This rapid release often results in swift drug absorption and consequent pharmacodynamic effects, although the timing and intensity can vary depending on the drug's properties. Prodrugs within these formulations require metabolic conversion to activate their pharmacodynamic effects,...
Modified-Release Drug Delivery Systems: Stimuli-Activated01:30

Modified-Release Drug Delivery Systems: Stimuli-Activated

Stimuli-activated drug delivery systems are designed to release drugs in response to specific physical, chemical, or biological stimuli. These systems often utilize hydrogels—three-dimensional, hydrophilic polymer networks capable of swelling in aqueous environments and retaining significant fluid volumes. Upon exposure to particular stimuli, these hydrogels undergo structural transitions that allow the embedded drug to be released. Due to this adaptive behavior, such systems are also called...
Modified-Release Drug Delivery Systems: Classification01:23

Modified-Release Drug Delivery Systems: Classification

Modified-release drug delivery systems improve drug efficacy and minimize side effects by controlling the rate and location of drug release. These systems fall into three categories: rate-programmed, stimuli-activated, and site-targeted.Rate-programmed systems release drugs at a predetermined rate, maintaining consistent therapeutic levels and reducing fluctuations that could lead to toxicity or subtherapeutic effects. These systems use polymeric matrices, reservoir-based designs, or osmotic...
Modified-Release Drug Delivery Systems: Overview01:19

Modified-Release Drug Delivery Systems: Overview

Modified-release dosage forms are designed to address the limitations of drugs with short biological half-lives. These forms maintain stable therapeutic drug concentrations over extended periods, reducing the need for frequent dosing. A consistent drug level helps minimize peak-trough fluctuations, which can reduce adverse effects, lower the risk of drug resistance, and improve overall treatment effectiveness.One common type of modified-release form is the extended-release (ER) formulation. ER...
Modified-Release Drug Delivery Systems: Influencing Factors01:20

Modified-Release Drug Delivery Systems: Influencing Factors

Modified-release drug delivery systems are designed to optimize the therapeutic effect of drugs by minimizing side effects, reducing the dosage required, and controlling drug release to align with pharmacokinetic and pharmacodynamic needs. The system depends on two key factors: the drug's release from the formulation and its movement through the body to the target site. Unlike conventional dosage forms, where absorption is the limiting step, the rate of drug release is the key determinant in...

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Related Experiment Video

Updated: Jul 16, 2026

Self-Nanoemulsification of Healthy Oils to Enhance the Solubility of Lipophilic Drugs
08:18

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Published on: July 27, 2022

Nano-Delivery Systems for Essential Oils in Chitosan-Based Biopolymer Packaging: Structure-Function Relationships and

Qin Liu1,2, Hanahati Kuerbanjiang3, Xiaofeng Ren1

  • 1School of Food and Biological Engineering, Jiangsu University, Zhenjiang 212013, China.

Foods (Basel, Switzerland)
|July 15, 2026
PubMed
Summary

This review synthesizes chitosan (CS)-based nano-delivery systems for essential oils (EOs) in active food packaging. It highlights how carrier design and multiscale organization impact film properties and food preservation performance.

Keywords:
active food packagingchitosancontrolled releaseessential oilsfood preservationinterfacial regulationnano-delivery systems

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Area of Science:

  • Food Science and Technology
  • Materials Science
  • Nanotechnology

Background:

  • Chitosan (CS) and essential oil (EO) packaging systems are widely studied.
  • A gap exists in understanding nano-delivery design's role in interfacial regulation, film evolution, release, and preservation performance within real food systems.

Purpose of the Study:

  • To review CS-based nano-delivery systems for EOs in active food packaging.
  • To emphasize the influence of carrier design and multiscale organization on functional performance.

Main Methods:

  • Discussed major nano-delivery strategies: nanoemulsions, nanoparticles, nanogels, Pickering emulsions, nanofibrous systems, and nanocomposites.
  • Evaluated effects on EO stabilization, dispersion, controlled release, film properties (microstructure, mechanical, barrier, thermal, optical), and antimicrobial/antioxidant activities.
  • Assessed preservation outcomes in various food products (fruits, vegetables, dairy, meat, aquatic).

Main Results:

  • Structure-function relationships across carrier, interface, and film-network levels were analyzed.
  • Distinguished between active and emerging smart packaging applications.
  • Identified challenges: EO variability, comparability issues, sensory limits, migration/regulatory concerns, and scalability.

Conclusions:

  • Future research should focus on mechanism-informed interfacial design and standardized evaluation.
  • Prioritize food-specific release-preservation correlations and scalable green manufacturing for advanced active and smart food packaging.