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Midface Hypoplasia and Cranial Base Morphology in Syndromic Craniosynostosis: A Comparative Analysis Study Using a Predictive Regression Model
Published on: November 4, 2025
Nasal Septal Deviation Classifications, Including the Mladina System, and Their Craniofacial Correlates: A Scoping
Rafał Nowak1,2, Filip Bliźniak3, Karolina Lubecka4
1Department of Otolaryngology and Maxillofacial Surgery, Institute of Medical Science, University of Zielona Góra, Ul. Zyty 28, 65-046 Zielona Gora, Poland.
Nasal septal deviation (NSD) is linked to specific nasomaxillary changes, not global facial asymmetry. Further research using standardized classifications like the Mladina system is needed for clearer insights into craniofacial morphology.
Area of Science:
- Dentistry
- Orthodontics
- Craniofacial Biology
Background:
- Nasal septal deviation (NSD) is a common condition potentially affecting craniofacial development.
- Existing research on NSD and craniofacial morphology uses varied methods and classifications.
- The Mladina classification is one method used to assess NSD.
Purpose of the Study:
- To map and synthesize evidence on the relationship between NSD classifications and craniofacial morphology.
- To review studies using various assessment methods, including the Mladina system.
Main Methods:
- A scoping review following Joanna Briggs Institute methodology.
- Extensive literature search across multiple databases without date or language restrictions.
- Inclusion of studies assessing NSD and relating it to craniofacial, maxillary, mandibular, dentofacial, or asymmetry outcomes.
Main Results:
- Six studies met inclusion criteria, showing significant heterogeneity.
- Consistent findings indicate NSD is associated with localized/transverse nasomaxillary changes (palate, maxilla, nasal floor, dentoalveolar region).
- Limited and inconsistent evidence exists for global facial asymmetry, maxillomandibular dimensions, and malocclusion.
Conclusions:
- NSD is not a uniform marker for global craniofacial abnormalities.
- NSD is more strongly associated with specific local and transverse nasomaxillary features.
- Future research requires standardized NSD classifications (e.g., Mladina) and 3D craniofacial assessments in homogeneous populations.
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