Related Experiment Video
Updated: Jul 17, 2026
09:10
Intestinal Epithelial Regeneration in Response to Ionizing Irradiation
Published on: July 27, 2022
Epithelial regeneration in the gastrointestinal tract
1Department of Biological Sciences, College of Bio-convergence, Dankook University, 119, Dandae-ro, Dongnam-gu, Cheonan-si, Chungcheongnam-do 31116, Republic of Korea; Center for Genome Engineering (CGE), Institute for Basic Science (IBS), 55, Expo-ro, Yuseong-gu, Daejeon 34126, Republic of Korea.
Current Opinion in Genetics & Development
|July 15, 2026
Summary
The intestine and stomach regenerate differently, with the intestine using Lgr5+ stem cells and the stomach using chief cells. Both share some regenerative pathways, but the role of Retinoic Acid (RA) signaling in stomach regeneration needs further study.
Area of Science:
- Gastrointestinal biology
- Stem cell research
- Regenerative medicine
Background:
- The gastrointestinal tract has significant regenerative capabilities.
- The intestine and stomach display unique regenerative strategies.
- Understanding these distinct mechanisms is crucial for tissue repair.
Purpose of the Study:
- To compare the cellular and molecular mechanisms of regeneration in the intestine and stomach.
- To explore conserved and divergent pathways in gastrointestinal tissue repair.
- To identify knowledge gaps, particularly regarding Retinoic Acid (RA) signaling in stomach regeneration.
Main Methods:
- Comparative analysis of existing literature on intestinal and gastric regeneration.
- Review of studies on stem cell populations (Lgr5+, p57+) and signaling pathways (YAP/TAZ, RA).
- Synthesis of findings to highlight similarities and differences in regenerative processes.
Main Results:
- Intestinal regeneration involves Lgr5+ stem cells and Revival stem cells (RevSCs), dependent on YAP/TAZ signaling.
- Gastric regeneration utilizes paligenosis, with quiescent p57+ chief cells dedifferentiating.
- Both organs show transient YAP/TAZ signaling activation during regeneration.
Conclusions:
- Intestinal and gastric regeneration differ in cellular origins but share some molecular pathways.
- The role of Retinoic Acid (RA) signaling in stomach regeneration remains an open question.
- This comparative review provides a foundation for future research into conserved regenerative mechanisms.
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