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Updated: Aug 6, 2026

Efficient Synthesis of All-Carbon Quaternary Centers via the Conjugate Addition of Functionalized Monoorganozinc Bromides
Published on: May 26, 2019
Synthesis of β-Carboline Derivatives via Rh(III)-Catalyzed Csp-Csp3 Bond Cleavage Using Alkynyl Quinol as C2
Lida Wang1, Zhonghong Chen1, Jiefu Luo1
1Basic Medicine Research and Innovation Center for Novel Target and Therapeutic Intervention, Ministry of Education, College of Pharmacy, Chongqing Medical University, Chongqing400016, China.
Abstract:
A straightforward access to diverse, highly functionalized β-carboline derivatives from 2-indolyl nitrone and alkynyl quinol has been established. This protocol features rhodium(III)-catalyzed Csp-Csp3 bond cleavage and a Kinugasa-type reaction involving N-O bond cleavage as key steps, enabling the assembly of β-carbolines in moderate to good yields with good anticancer activity.
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