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Identification of the Novel HLA-DRB1*15:237 Allele by Next-Generation Sequencing
Qimin Wu1, Nanying Chen1, Wenwen Pi1
1HLA Typing Laboratory, Blood Center of Zhejiang Province, Hangzhou, China.
HLA
|July 21, 2026
Summary
A novel Human Leukocyte Antigen (HLA) allele, HLA-DRB1*15:237, has been identified. It differs from the common HLA-DRB1*15:01:01:01 allele by a single nucleotide substitution.
Area of Science:
- Immunogenetics
- Molecular Biology
Background:
- Human Leukocyte Antigen (HLA) genes are crucial for immune response.
- Polymorphisms in HLA genes contribute to diverse immune functions and disease susceptibility.
Purpose of the Study:
- To characterize a newly identified HLA-DRB1 allele.
- To document sequence variations within the HLA-DRB1 locus.
Main Methods:
- High-resolution HLA typing was performed.
- Nucleotide sequencing was utilized to identify sequence differences.
Main Results:
- A novel HLA allele, designated HLA-DRB1*15:237, was discovered.
- This new allele is distinguished from HLA-DRB1*15:01:01:01 by a single nucleotide substitution (C>G) at position 568.
Conclusions:
- The identification of HLA-DRB1*15:237 expands the known HLA allele repertoire.
- This finding contributes to a more comprehensive understanding of HLA polymorphism.
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