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Sequencing of mRNA from Whole Blood using Nanopore Sequencing
Published on: June 3, 2019
Identification of the Novel HLA-B*55:02:18 Allele Using Nanopore Sequencing Technology
Zhipan Wu1, Fang Wang1, Lina Dong1
1HLA Typing Laboratory, Blood Center of Zhejiang Province, Hangzhou, China.
HLA
|July 21, 2026
Summary
A novel Human Leukocyte Antigen B variant, HLA-B*55:02:18, has been identified. This new HLA allele differs from a known allele by a single nucleotide substitution.
Area of Science:
- Immunogenetics
- Molecular biology
Background:
- Human Leukocyte Antigen (HLA) genes are crucial for immune response.
- Polymorphisms in HLA genes contribute to diverse immune capabilities.
Purpose of the Study:
- To characterize a newly identified HLA-B allele.
- To detail the specific genetic variation differentiating this allele.
Main Methods:
- Nucleotide sequencing of the HLA-B gene.
- Comparison of DNA sequences between known and novel alleles.
Main Results:
- A novel HLA-B allele, designated HLA-B*55:02:18, was identified.
- This allele differs from HLA-B*55:02:01:01 by a single nucleotide substitution (G>A) at position 963.
Conclusions:
- The discovery of HLA-B*55:02:18 expands the known HLA-B allele repertoire.
- This specific nucleotide change may have implications for immune recognition or function.
