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![[(DPEPhos)(bcp)Cu]PF6: A General and Broadly Applicable Copper-Based Photoredox Catalyst](/_next/image?url=https%3A%2F%2Fcloudfront.jove.com%2FCDNSource%2Fteasers%2F59739.jpg&w=3840&q=50)
[(DPEPhos)(bcp)Cu]PF6: A General and Broadly Applicable Copper-Based Photoredox Catalyst
Published on: May 21, 2019
Photoredox/Cobalt Cooperative Catalysis for Divergent Selective Isomerization of N-Allylamides
Xingxing Zhu1, Mingbao Zhang2, Yuan-Gen Gu2
1Department of Nuclear Medicine, The First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei230001, China.
Abstract:
Enamides are extremely important structural units, which are widely present in natural products and bioactive compounds and play a crucial role in the pharmaceutical field. Although many methods for synthesizing enamides have been developed, the obtained enamides usually suffer from poor selectivity and low yield. Herein, we report a divergent and selective isomerization reaction of N-allylamides under a visible light-driven photoredox cobalt-catalyzed system. This strategy enables the efficient synthesis of various enamides with excellent stereoselectivity. Notably, by simply switching the ligand in the reaction, both E- and Z-isomers can be obtained with high stereoselectivity (E/Z up to >20:1; Z/E up to 5.3:1) and good yields (58-92%) under mild conditions, along with a broad substrate scope and good functional group tolerance.
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