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Trajectory of Ascites Pressure and Outcomes of Patients With Cirrhosis Undergoing Paracentesis
Nikhilesh R Mazumder1,2, Max Macgregor1, John D Rice3
1Division of Gastroenterology and Hepatology, University of Michigan, Ann Arbor, Michigan, USA.
Introduction:
Ascites severity is an important prognostic marker of liver disease. We hypothesize that ascites pressure correlates with outcomes of patients undergoing therapeutic paracentesis.
Methods:
Adults with portal hypertensive ascites (n = 87) undergoing therapeutic paracentesis (n = 261) had pressure measured during drainage using a noninvasive manometer setup and were followed for 365 days.
Results:
Pressure drop during paracentesis was associated with event-free survival after adjusting for Model for End Stage Liver Disease 3.0 and age (adjusted hazard ratio 0.43 per 5 cmH 2 O, 95% confidence interval [0.21, 0.90], P = 0.02), but volume drained was not.
Discussion:
Ascites pressure provides Model for End Stage Liver Disease-independent prognostic information in patients undergoing paracentesis.
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