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Sodium pyruvate treatment for hyperkeratotic disorders
Southern Medical Journal
|March 1, 1979
Summary
5% sodium pyruvate in Eucerin effectively treated congenital hyperkeratosis disorders. This topical treatment was most effective for severe cases and well-tolerated, suggesting pyruvate
Area of Science:
- Dermatology
- Biochemistry
Background:
- Congenital hyperkeratosis disorders are characterized by excessive skin thickening.
- Current treatments may have limitations in efficacy or tolerability.
Purpose of the Study:
- To evaluate the efficacy and safety of 5% sodium pyruvate in Eucerin for treating congenital hyperkeratosis.
Main Methods:
- Topical application of a 5% sodium pyruvate in Eucerin formulation.
- Clinical assessment of hyperkeratosis severity and skin irritation.
Main Results:
- The formulation demonstrated significant efficacy in reducing hyperkeratosis.
- Treatment was most effective in disorders with the most severe hyperkeratosis.
- The formulation was non-irritating, even with extensive use.
Conclusions:
- Sodium pyruvate in Eucerin is a safe and effective topical treatment for congenital hyperkeratosis.
- Pyruvate's efficacy may be linked to its low pKa (pKa of pyruvic acid).