Related Experiment Video
Updated: Aug 6, 2026
Time-resolved Photophysical Characterization of Triplet-harvesting Organic Compounds at an Oxygen-free Environment Using an iCCD Camera
Published on: December 27, 2018
Engineering J-Aggregated Organic Dyes for Enhanced Phototheranostics
Xue Lian Zou1, Nan Li1, Na Zhao1
1Key Laboratory of Applied Surface and Colloid Chemistry of MOE, Key Laboratory of Macromolecular Science of Shaanxi Province, School of Chemistry & Chemical Engineering, Shaanxi Normal University, Xi'an 710119, China.
J-aggregation overcomes limitations in organic dyes for precise tumor phototheranostics. This strategy enhances imaging and therapeutic efficiencies by controlling molecular stacking, advancing clinical applications.
Area of Science:
- Biomedical engineering
- Materials science
- Oncology
Background:
- Precision phototheranostics for malignant tumors is a key research area.
- Aggregation-caused quenching (ACQ) limits the efficacy of conventional organic dyes in tumor theranostics.
Purpose of the Study:
- To elucidate the relationship between molecular stacking and theranostic performance using the exciton-coupling model.
- To summarize recent advancements in J-aggregate applications for tumor phototheranostics.
Main Methods:
- Utilized the exciton-coupling model to analyze molecular stacking modes and their impact on organic dye properties.
- Systematically reviewed literature on J-aggregate applications in tumor imaging and therapy.
Main Results:
- J-aggregation suppresses ACQ, leading to red-shifted spectra, enhanced molar extinction coefficients, and improved photothermal and reactive oxygen species generation efficiencies.
- Demonstrated the effectiveness of J-aggregates in fluorescence/photoacoustic imaging, photothermal therapy, photodynamic therapy, and multimodal theranostics.
Conclusions:
- J-aggregated organic dyes offer a promising strategy to overcome ACQ limitations and advance tumor phototheranostics.
- Provides theoretical insights and design principles for developing novel J-aggregated dyes and precise theranostic systems for clinical translation.
More Related Videos
08:51Scale-up Chemical Synthesis of Thermally-activated Delayed Fluorescence Emitters Based on the Dibenzothiophene-S,S-Dioxide Core
Published on: October 24, 2017
06:25Step-by-Step Guide for Harnessing Organic Light Emitting Diodes by Solution Processed Device Fabrication of a TADF Emitter
Published on: November 7, 2025