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Updated: Jan 16, 2026

Near Infrared Photoimmunotherapy for Mouse Models of Pleural Dissemination
Published on: February 9, 2021
An endoplasmic reticulum-targeted NIR-II type I AIE photosensitiser for triggering pyroptosis
Xinyu Li1, Lijin Yang1, Bingbing He1
1Key Laboratory of Applied Surface and Colloid Chemistry of Ministry of Education, Key Laboratory of Macromolecular Science of Shaanxi Province, School of Chemistry & Chemical Engineering, Shaanxi Normal University, Xi'an, 710119, P. R. China. nli@snnu.edu.cn.
None:
In this work, we developed an endoplasmic reticulum-targeted NIR-II photosensitizer (TI-ER), which exhibits type I ROS generation and photothermal capabilities. After formulation into nanoparticles (NPs), TI-ER NPs were efficiently internalized by cancer cells and induced pyroptosis under 635 nm laser irradiation, efficiently ablating both cancer cells and multicellular tumor spheroids.
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