Carbonic anhydrase VI
Tashnuva Rifat1, Mathias Sanchez Machado1, Marc A Ilies1
1Department of Pharmaceutical Sciences, Temple University School of Pharmacy, Philadelphia, PA, United States.
The Enzymes
|July 22, 2026
Summary
Carbonic anhydrase VI (CA VI) is a unique secreted enzyme found throughout the human body. This review details its structure, function, and modulation by inhibitors and activators.
Area of Science:
- Biochemistry
- Human Physiology
Background:
- Carbonic anhydrase VI (CA VI) is the sole secreted carbonic anhydrase in humans.
- It is found in various bodily fluids and tissues, including saliva, milk, GI tract, and upper respiratory tract.
Purpose of the Study:
- To provide a comprehensive overview of Carbonic anhydrase VI.
- To explore its structure, activity, and physiological and pathological roles.
Main Methods:
- Literature review and synthesis of existing research on CA VI.
- Analysis of CA VI's interaction with inhibitors and activators.
Main Results:
- CA VI exhibits diverse physiological roles across multiple human systems.
- Its activity can be modulated by specific classes of inhibitors and activators.
Conclusions:
- Carbonic anhydrase VI is a significant enzyme with widespread distribution and functional importance.
- Understanding CA VI's modulation is crucial for potential therapeutic applications.
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