Carbonic anhydrase VI
Tashnuva Rifat1, Mathias Sanchez Machado1, Marc A Ilies1
1Department of Pharmaceutical Sciences, Temple University School of Pharmacy, Philadelphia, PA, United States.
Abstract:
Carbonic anhydrase VI is the only secreted human carbonic anhydrase, identified in saliva, milk, colostrum, in the esophagus and in different parts of the GI tract, in the upper respiratory tract, in lacrimal glands, in serum and in other parts of the human body. The chapter provides a detailed overview of its structure, activity, physiological and pathological roles of CA VI and of its susceptibility to different classes of inhibitors and activators used to modulate its activity.
Related Concept Videos
Bicarbonate-Carbonic Acid Buffer
ATP Driven Pumps III: V-type Pumps
The peripheral or cytosolic V1 domain with eight subunits is involved in ATP hydrolysis. The integral or transmembrane V0 domain containing at least five subunits...
Renal Regulation of Acid-Base Balance
In the kidneys, cells within the proximal convoluted tubules (PCT) and the collecting ducts secrete hydrogen ions (H+) into the tubular fluid. Specifically, in the PCT, Na+/H+ antiporters secrete H+ while reabsorbing Na+.
However, the intercalated cells in...
Aquaporins
Respiratory Regulation of Acid-Base Balance
When carbon dioxide levels increase in the blood, more H+ and HCO3⁻ are produced, leading to a...
Electron Transport Chain: Complex III and IV


